"Peprotech"

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Murine IL-7. Anti­Murine IL-7­specific antibody was purified by affinity chromatography employing an immobilized Murine IL-7 matrix.

Supplier: Peprotech

Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand exerts no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant Human Flt3-Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues.

Supplier: Peprotech

PlGF-1 is an angiogenic factor that belongs to the cysteine-knot superfamily of growth factors. PlGF-1 is expressed in placental tissues, the colon, and mammary carcinomas. It signals through the VEGFR-1/FLT1 receptor, and stimulates endothelial cell proliferation and migration. Recombinant Human PlGF-1 is a 29.7 kDa disulfide-linked homodimeric protein of two 132 amino acid polypeptide chains.

Supplier: Peprotech

CTGF is a member of the CCN family of secreted cysteine-rich regulatory proteins, and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells. CTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial and epithelial cells, and binds to IGF, TGF β1 and BMP-4. Cell migration and adhesion are signaled through binding to specific cell surface integrins and to heparin sulfate proteoglycans CTGF (98 a.a.), a lower molecular weight isoform containing the C-terminal portion of the full length CTGF protein, exerts full heparin binding, cell adhesion, and mitogenic CTGF activity. Mature Human CTGF is a 38.0 kDa secreted protein containing 323 amino acid residues. CTGF is comprised of four distinct structural domains (modules), which are identified as IGF binding protein (IGFBP), von Willebrand Factor C (VWFC), thrombospondin type-I (TSP type-I), and C-terminal cysteine knot-like (CTCK) domains. Full length CTGF can be proteolytically cleaved in certain tissues to yield N-terminal truncated isoforms, which, depending on the isoform, contain only the TSP type-I and CTCK domains or contain only the CTCK domain. Recombinant Human CTGF is an 11.0 kDa protein consisting of 97 amino acid residues.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human IFN-γ. Anti­Human IFN-γ­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

WISP-3 is a member of the CCN family of secreted cysteine rich regulatory proteins. It is predominantly expressed in the adult kidney, testis, and fetal kidney, but it is also found with weaker expression in the placenta, ovary, prostate, small intestine, and skeletally-derived cells. WISP-3 is required for normal postnatal skeletal growth and cartilage homeostasis. Recombinant Human WISP-3 is a 36.8 kDa protein containing 331 amino acid residues. It is composed of four distinct structural domains (modules): the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the thrombospondin type-1 repeat (TSP type-1) domain, and a C-terminal cysteine knot-like (CTCK) domain.

Supplier: Peprotech

Myostatin is a TGF-β family member that acts as an inhibitor of skeletal muscle growth. This muscle-specific cytokine interacts with Activin type I and type II receptors, and suppresses myoblast proliferation by arresting cell-cycle in the G1 phase. Suppression of myostatin activity facilitates muscle formation, and may be useful in reducing and/or preventing adiposity and type-2 diabetes. Myostatin activity can be blocked by the activin-binding protein follistatin, and by the propeptide of myostatin. The amino acid sequence of mature myostatin is extremely conserved across species, and is the same in murine, rat, chicken, turkey, porcine, and human. Myostatin is expressed as the C-terminal part of a precursor polypeptide, which also contains a short N-terminal signal sequence for secretion, and a propeptide of 243 amino acids. After dimerization of this precursor, the covalent bonds between the propeptide and the mature ligand are cleaved by furin-type proteases. However, the resulting two proteins remain associated through non-covalent interactions, and are secreted as a latent complex. Recombinant Human/Murine/Rat Myostatin is a 25.0 kDa protein consisting of two identical 109 amino acid polypeptides linked by a single disulfide bond.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human TARC (CCL17). Anti­Human TARC (CCL17)­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes, and has been shown to inhibit angiogenesis. Recombinant Human PF-4 (CXCL4) is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Supplier: Peprotech

Monoclonal AntibodyProduced in BALB/c-mice immunized with highly pure Recombinant Human FGF-5. Anti­Human FGF-5­specific antibody was purified from ascites fluid by Protein A affinity chromatography.

Supplier: Peprotech

Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and, along with Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung and in allergic reactions. Recombinant Murine Eotaxin (CCL11) is an 8.4 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Supplier: Peprotech

Human IL-37 Recombinant Protein, Purity: >95% by SDS and HPLC, Source: E.coli, Biological Activity: Ability to bind Interleukin-18 Binding Protein isoform a (IL-18 BPa) in functional ELISA, Synonyms: Interleukin-37,

Supplier: Peprotech

The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Human LEC (CCL16). Anti­Human LEC (CCL16)­specific antibody was purified by affinity chromatography employing an immobilized Human LEC matrix.

Supplier: Peprotech

Monoclonal AntibodyProduced in BALB/c-mice immunized with highly pure Recombinant Human MCP-4 (CCL13). Anti­Human MCP-4 (CCL13)­specific antibody was purified from cell culture by Protein A affinity chromatography.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human IGF-BP7. Anti­Human IGF-BP7­specific antibody was purified by affinity chromatography and then biotinylated.