"Peprotech"

Supplier: Peprotech

IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activities primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been linked to rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant Rat IL-15 is a 13.5 kDa protein consisting of 115 amino acid residues.

Supplier: Peprotech

Monoclonal AntibodyProduced in BALB/c x C57BL/6 F1-mice immunized with highly pure Recombinant Human TNF-α. Anti­Human TNF-α­specific antibody was purified from ammonium sulfate precipitation followed by ion exchange chromatography.

Supplier: Peprotech

Pleiotrophin and Midkine are structurally related heparin-binding neurotrophic factors, whose expression is developmentally regulated. The expression pattern of these neurotrophic factors suggests function in neurogenesis, cell migration, secondary organogenetic induction, and mesoderm epithelial interaction. The expression of PTN increases during the process of brain embryogenesis, and reaches maximum levels at time of birth. The physiological roles of PTN and Midkine are largely unknown, but these neurotrophins have been implicated in the pathogenesis of neuroblastomas. Recombinant Human Pleiotrophin is a 15.4 kDa protein containing 136 amino acid residues and five intra-molecular disulfide bonds.

Supplier: Peprotech

IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant Murine IP-10 (CXCL10) is an 8.7 kDa protein consisting of 77 amino acids, including the four conserved cysteine residues present in CXC chemokines.

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RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant Rat RANTES (CCL5) is a 7.9 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Supplier: Peprotech

Murine IL-12 p40 Recombinant Protein, Purity: >95%, Source: HEK293 cells, Biological Activity: Determined by its ability to inhibit the proliferative effect of 2 ng/ml mIL-12p70 in T-cell enriched PBMCs, Synonym

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Produced from sera of goats immunized with highly pure Recombinant Rat IL-1α. Anti­Rat IL-1α­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant Rat IL-2 is a 15.3 kDa protein containing 134 amino acid residues.

Supplier: Peprotech

Monoclonal AntibodyProduced in BALB/c-mice immunized with highly pure Recombinant Rat IL-2. Anti­Rat IL-2­specific antibody was purified from cell culture by Protein A affinity chromatography.

Supplier: Peprotech

DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant Human DKK-1 expressed in

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sIL-4 Receptor alpha, Polyclonal antibody, Host: Rabbit, Species: Human, Immunogen: CHO cells derived Recombinant Human IL-4 Receptor A, Application: Sandwich ELISA, Western Blot, Purity: affinity chromatography, Size: 100UG

Supplier: Peprotech

FGF-6 is a secreted, heparin-binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-6 is expressed in leukemia cell lines with platelet megakaryocytic differentiation potential. It signals through FGFR 1c, 2c, and 4. Recombinant Human FGF-6 is an 18.7 kDa protein consisting of 168 amino acid residues.

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Produced from sera of rabbits immunized with highly pure Recombinant Human Osteopontin. Anti­Human Osteopontin­specific antibody was purified by affinity chromatography employing an immobilized Human Osteopontin matrix.

Supplier: Peprotech

Human IGF-I, Polyclonal Antibody, Source: Rabbit, Preparation: purified by affinity chromatography employing immobilized hIGF-I matrix, Immunogen:E.coli derived Recombinant Human IGF-I, Application:ELISA, Western Blot, Neutralization, Immunohistochemistry, 1mg

Supplier: Peprotech

The FGF family plays a central role during prenatal development and postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. The FGF ligands bind to a family of type I transmembrane tyrosine kinase receptors, which leads to dimerization and activation by sequential autophosphorylation of specific tyrosine residues. Four genes encoding structurally related FGF receptors (FGFR-1 to -4) are known. Alternative splicing of the mRNAs generates numerous forms of FGFR-1 to -3. Alternate forms of FGF receptors can exhibit different specificities with respect to ligand binding. For example, the form designated as FGFR1a (IIc) interacts predominantly with FGF-acidic (FGF1) and FGF-basic (FGF2). A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). Recombinant Human FGFR2a (IIIc) Fc is a 65.6 kDa protein containing 589 amino acids. Under reducing conditions, FGFR2a migrates between 100-110 kDa on SDS-PAGE gel.

Supplier: Peprotech

MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells, and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells, and exerts HIV-suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity, but retains HIV-suppressive activity. Recombinant Human MDC (CCL22) is an 8.0 kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.