"Peprotech"

Supplier: Peprotech

Monoclonal AntibodyProduced in BALB/c x ICR F1-mice immunized with highly pure Recombinant Human IL-1β. Anti­Human IL-1β­specific antibody was purified from ascites fluid by Protein A affinity chromatography.

Supplier: Peprotech

VCAM is a 110 kDa, cell surface integral membrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. The primary function of VCAM-1 is the mediation of leukocyte endothelial cell adhesion and signal transduction. VCAM-1 may play a vital role in the development of several diseases, including atherosclerosis and rheumatoid arthritis. The human VCAM-1 gene codes for a 715 amino acid transmembrane glycoprotein containing a 19 amino acid cytoplasmic domain, a 22 amino acid transmembrane domain, and a 674 amino acid extracellular domain. Recombinant Murine VCAM-1 is a 74.4 kDa glycoprotein comprising the extracellular domain (674 amino acid residues) of VCAM-1. Monomeric glycosylated VCAM-1 migrates at an apparent molecular weight of approximately 87-97 kDa by SDS-PAGE analysis under reducing conditions.

Supplier: Peprotech

Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-gamma-stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and, along with Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung and in allergic reactions. Recombinant Human Eotaxin is an 8.3 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Supplier: Peprotech

Murine TFF-1 Recombinant Protein, Purity: >98%, Source: E.coli, Expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair, Synonyms: Breast Cancer Estroge

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human IL-6. Anti­Human IL-6­specific antibody was purified by affinity chromatography employing an immobilized Human IL-6 matrix.

Supplier: Peprotech

The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Human MCP-3 (CCL7) is a 9.0 kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Supplier: Peprotech

Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant Human BRAK (CXCL14) is a 9.4 kDa protein containing 77 amino acid residues.

Supplier: Peprotech

IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include: inducing the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells; the stimulation of IgG production in conjunction with IL-4; and the induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Human IL-21 is a 15.4 kDa protein consisting of 132 amino acid residues.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human TECK (CCL25). Anti­Human TECK (CCL25)­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Recombinant Human TLR-4 is a 69.3 kDa glycoprotein containing 609 amino acid residues of the TLR-4 extracellular domain. As a result of glycosylation, Recombinant Human TLR-4 migrates with an apparent molecular mass of approximately 90-100 kDa by SDS-PAGE gel, under reducing and non-reducing conditions.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human MIA. Anti­Human MIA­specific antibody was purified by affinity chromatography employing an immobilized Human MIA matrix.

Supplier: Peprotech

WISP-1 is a member of the CCN family of secreted, cysteine-rich regulatory proteins. It is expressed in the heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. WISP-1 is a β-catenin-regulated protein that can contribute to tumorigenesis, and has also been shown to play a role in bone development and fracture repair. Recombinant Human WISP-1 is a 38.1 kDa protein containing 345 amino acid residues. It is composed of four distinct structural domains (modules): the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the thrombospondin type-1 repeat (TSP type-1) domain, and a C-terminal cysteine knot-like (CTCK) domain.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Murine IL-21. Anti­Murine IL-21­specific antibody was purified by affinity chromatography employing an immobilized Murine IL-21 matrix.

Supplier: Peprotech

VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. VEGF signals through three receptors; fms- like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Due to its increased acidity, VEGF Recombinant Human VEGF

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human BRAK (CXCL14). Anti­Human BRAK (CXCL14)­specific antibody was purified by affinity chromatography employing an immobilized Human BRAK matrix.

Supplier: Peprotech

Relaxin-3 is a secreted protein structurally related to insulin that is expressed primarily in the brain and central nervous system. Relaxin-3 has been identified as the ligand for the GPCR135 receptor, previously known as “somatostatin-like” or “angiotensin-like” peptide receptor, and has also been identified for binding specifically to the LGR7 receptor, previously identified as an “orphan” G protein-coupled receptor. Signaling by relaxin-3 through its target receptors is, most likely, part of a CNS processing system, activated in response to signaling by neuropeptides and other factors. Intracerebroventricular injections of relaxin-3 have been shown to cause a significant increase of food intake and body weight in Wistar rats. Recombinant Human Relaxin-3 is a 5.5 kDa, disulfide-linked, heterodimeric protein consisting of a 24 amino acid A-chain and a 27 amino acid B-chain.