1624 Results for: "Peprotech"

Supplier: Peprotech

Animal-Free Human IL-37 Recombinant Protein, Purity: >95%, Source: E.coli, Biological Activity: By its ability to bind Interleukin-18 Binding Protein isoform a (IL-18 BPa) in functional ELISA, Synonyms: I

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human BD-5. Anti­Human BD-5­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Murine EGF. Anti­Murine EGF­specific antibody was purified by affinity chromatography employing an immobilized Murine EGF matrix.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Murine Eotaxin-2 (CCL24). Anti­Murine Eotaxin-2 (CCL24)­specific antibody was purified by affinity chromatography employing an immobilized Murine Eotaxin-2 matrix.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human 4-1BB Ligand. Anti­Human 4-1BB Ligand­specific antibody was purified by affinity chromatography employing an immobilized Human 4-1BB Ligand matrix.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human Midkine. Anti­Human Midkine­specific antibody was purified by affinity chromatography employing an immobilized Human Midkine matrix.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Murine EGF. Anti­Murine EGF­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Human MIP-5 (CCL15). Anti­Human MIP-5 (CCL15)­specific antibody was purified by affinity chromatography employing an immobilized Human MIP-5 matrix.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Rat IFN-γ. Anti­Rat IFN-γ­specific antibody was purified by affinity chromatography employing an immobilized Rat IFN-γ matrix.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Murine IFN-γ. Anti­Murine IFN-γ­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Murine MCP-3 (CCL7). Anti­Murine MCP-3 (CCL7)­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human Galectin-1. Anti­Human Galectin-1­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human gAcrp30/Adipolean Variant. Anti­Human gAcrp30/Adipolean Variant­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Murine Resistin. Anti­Murine Resistin­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Human LD78β (CCL3L1). Anti­Human LD78β (CCL3L1)­specific antibody was purified by affinity chromatography employing an immobilized Human LD78β matrix.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human LIGHT. Anti­Human LIGHT­specific antibody was purified by affinity chromatography employing an immobilized Human LIGHT matrix.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Human sFas Ligand. Anti­Human sFas Ligand­specific antibody was purified by affinity chromatography employing an immobilized Human sFas Ligand matrix.

Supplier: Peprotech

The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36alpha (IL-1F6), IL-36beta (IL-1F8), and IL-36gamma (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-kappaB signaling induced by either IL-36alpha, beta or gamma by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant Murine IL-36RA is an E. coli-derived 16.9 kDa protein containing 154 amino acid residues.

Supplier: Peprotech

The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Human MCP-1 is an 8.6 kDa protein containing 76 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines.

Supplier: Peprotech

IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant Murine IP-10 is an 8.7 kDa protein consisting of 77 amino acids, including the four conserved cysteine residues present in CXC chemokines.

Supplier: Peprotech

IL-12 is a potent regulator of cell-mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells, and induces the development of IFN-gamma-producing Th1 cells. PeproTech's Recombinant Human IL-12 p70, derived from HEK293 cells, is a heterodimeric glycoprotein consisting of disulfide-linked p35 and p40 subunits (503 total amino acid residues). The calculated molecular weight of Human IL-12 p70 is 57.2 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of 65-70 kDa based on SDS-PAGE gel, under non-reducing conditions.

Supplier: Peprotech

IL-34 is a homodimeric cytokine that is expressed in a range of tissues that include spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1, stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. Recombinant Human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag.

Supplier: Peprotech

Complement 5a (C5a) is an enzymatically generated glycoprotein belonging to the anaphylatoxin family of structurally and functionally related proteins. Generated upon the activation of the complement system, C5a, together with C4a, C3a, and the membrane attack complex (C5b-9), functions as a central player in host defense by inducing smooth muscle cell contraction, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes through cell degranulation. In addition to acting as a direct mediator of localized inflammatory response, C5a also initiates both the synthesis and release of IL-8 from monocytes and bronchial epithelial cells, stimulates the proliferation of neurons and hepatocytes, and functions as a potent chemoattractant. Where C5a deficiency, a rare defect of the complement pathway caused by the mutation of the C5a gene, is associated with susceptibility to severe infections, excessive C5a activation has been linked to liver fibrosis, sepsis, adult respiratory distress syndrome, rheumatoid arthritis, Alzheimer’s disease, and ischemic heart disease. Human C5a shares 60% and 54% sequence identity to mouse and rat C5a, respectively. The human C5 gene encodes a 1,676 amino acid glycoprotein that is comprised of a disulfide-linked C5 alpha and a C5 beta chain, the former of which contains the active, 74 amino acid C5a anaphylatoxin chain. Recombinant Human C5a is an 8.28 kDa glycoprotein containing the 74 amino acid residues of the C5a anaphylatoxin chain.

Supplier: Peprotech

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. BD-4 is expressed in the testes, stomach, uterus, neutrophils, thyroid, lungs and kidneys. In addition to its direct antimicrobial activities, BD-4 is chemoattractant towards human blood monocytes. Recombinant Human BD-4 is a 6.0 kDa protein containing 50 amino acid residues.

Supplier: Peprotech

Viral MIP-2 (vMIP-2) is a chemokine analog encoded by the human herpes virus, and has been shown to have antagonist activity towards several chemokine receptors. Recombinant Viral MIP-2 is a 7.9 kDa protein consisting of 70 amino acids, including the four highly conserved cysteine residues present in CC chemokines.

Supplier: Peprotech

EG-VEGF is a secreted angiogenetic mitogen growth factor expressed in the steroidogenic glands, ovary, testis, adrenal gland, and placenta. EG-VEGF induces proliferation, migration, and fenestration (formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. The murine EG-VEGF gene codes for a 105 amino acid polypeptide containing an N-terminal signal sequence of 19 amino acids. Recombinant Murine EG-VEGF is a 9.6 kDa protein consisting of 86 amino acid residues, including ten cysteine residues that potentially form five pairs of intra-molecular disulfide bonds.

Supplier: Peprotech

IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP6, which specifically inhibits IGF-II actions, is produced by bone cells and is the major IGF-BP present in cerebrospinal fluid. IGF-BP6 has been shown to inhibit IGF-II-dependent cancers such as neuroblastoma, colon cancer and rhabdomyosarcoma. Recombinant Human IGF-BP6 has a calculated mass of 22.3 kDa and consists of 213 amino acid residues, including the IGF-BP domain and thyroglobulin type-I domain. Recombinant Human IGF-BP6 migrates at an apparent molecular weight of approximately 23.0-30.0 kDa by SDS-PAGE analysis under non-reducing conditions.

Supplier: Peprotech

ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in the liver and brain, and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease. Recombinant Human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues.

Supplier: Peprotech

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages, and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant Rat GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acid residues.

Supplier: Peprotech

RELMβ (Resistin-like molecule β/FIZZ2) is a disulfide-linked, homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMβ, and its molecular targets, are not fully known, but it has been suggested that it plays a regulatory role during inflammation, and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly, the molecular structure of RELMβ is highly homologous to that of the adipose-derived cytokines, resistin and RELMα. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELMβ is an 18.0 kDa protein, consisting of two identical 83 amino acid polypeptide chains linked by a single disulfide bond.