"Ligases"

Supplier: Proteintech

LIG1, also named as LRIG1, acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.

Supplier: Genetex

Rabbit Polyclonal antibody to Ligase 1 (ligase I DNA ATP-dependent) Purity: Protein G purified Species Reactivity: Human Tested Applications: WB Pkg Size: 200 ul

Supplier: New England Biolabs (NEB)

StickTogether Buffer is supplied with T3, T7, Hi-T4 and Salt-T4 DNA ligases.

Supplier: Genetex

Rabbit polyclonal antibody to DNA ligase I (ligase I, DNA, ATP-dependent)

Supplier: Lucigen

The NxGen® T4 DNA Ligases from LGC Biosearch (Lucigen) come in a range of highly pure grades specifically for next-generation sequencing (NGS). This enzyme catalyses the formation of a phosphodiester bond between the terminal 5′ phosphate and 3′ hydroxyl groups of duplex DNA or RNA and efficiently joins blunt and cohesive ends, and repairs single stranded nicks in duplex DNA, RNA, or DNA/RNA hybrids.

Supplier: New England Biolabs (NEB)

Catalyzes the formation of a phosphodiester bond between juxtaposed 5'-phosphate and 3'-hydroxyl termini in duplex DNA containing cohesive ends.

Supplier: Abcam

Rabbit Polyclonal DNA Ligase III/LIG3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human LIG3 aa 100-450.

Supplier: New England Biolabs (NEB)

Catalyzes the formation of a phosphodiester bond between juxtaposed 5' phosphate and 3' hydroxyl termini in duplex DNA or RNA.

Supplier: Abcam

Rabbit Recombinant Monoclonal DNA Ligase III/LIG3 antibody. BSA and Azide free. Suitable for Flow Cyt (Intra), IHC-P, IP, ICC/IF, WB and reacts with Human, Mouse, Rat samples.

Supplier: Genetex

Eukaryotic DNA ligases are ATP-dependent enzymes that catalyse the joining of single and double-strand DNA breaks, which is an essential final step in DNA replication, recombination and repair. Four biochemically distinct DNA ligases, termed ligases I-IV, have been identified in mammalian cells. DNA ligase I is functionally homologous to the DNA ligase encoded by the Saccharomyces cerevisiae Cdc9 gene. The joining of Okazaki fragments during lagging strand DNA replication in mammalian cells is due to DNA ligase I. A combination of DNA polymerase epsilon, PCNA, replication factor C, replication protein A, and DNA ligase I is well-suited to the task of creating nucleotide excision repair patches.

Supplier: Genetex

Rabbit Polyclonal antibody to DNA ligase III (ligase III, DNA, ATP-dependent)

Supplier: Genetex

Rabbit polyclonal antibody to DNA ligase IV (ligase IV, DNA, ATP-dependent)

Supplier: Genetex

Mouse polyclonal to DNA ligase I

Supplier: Genetex

Rabbit Polyclonal antibody to DNA ligase III (ligase III, DNA, ATP-dependent)

Supplier: Bioss

Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its abilty to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.

Supplier: Genetex

Mouse monoclonal [10H5] to DNA ligase I