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385 results for "FUJIFILM IRVINE SCIENTIFIC, INC"

385 Results for: "FUJIFILM IRVINE SCIENTIFIC, INC"

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Human Recombinant IFNalpha 2b (from E. coli)

Human Recombinant IFNalpha 2b (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Interferon-alpha 2b (IFN-α2b) is a type I interferon made by leukocytes during viral infection. The JAK-STAT pathway mediates the antiviral and anti-cell proliferation activities of IFN-α2b. IFN-α proteins are widely used as standard treatments during antiviral and antineoplastic therapies. The IFN-α2b variant differs from IFN-α2a by one amino acid.

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Mouse Recombinant FGF-Basic (from E. coli)

Mouse Recombinant FGF-Basic (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Basic fibroblast growth factor (FGF-basic), also known as FGF-2, is expressed by endothelial cells and is a mediator of angiogenesis. FGF-basic also has cardioprotective functions during heart injury. The application of FGF-basic is a critical component for human embryonic stem cell culture systems and is necessary for maintaining human embryonic stem cells in an undifferentiated state.

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Mouse Recombinant IL-13 (from E. coli)

Mouse Recombinant IL-13 (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Interleukin 13 (IL-13) is a cytokine secreted from type 2 T helper (Th2) cells. IL-13 has overlapping functions with interleukin 4 (IL-4), including the induction of immunoglobulin E (IgE) secretion from B cells, and the inhibition of interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), interleukin 8 (IL-8), and interleukin 6 (IL-6) inflammatory cytokine expression. IL-13 also regulates immune cell inflammation in response to the pathophysiological changes of surrounding non-immune cells. The IL-13 receptor consists of the IL-4Ra and IL-13Ra1 subunits. IL-13 can also bind the IL-13Ra2 receptor with high affinity. IL-13 functions are mediated through the JAK/STAT signaling pathway. Human and mouse IL-13 are cross-reactive.

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Rat Recombinant IL-17A (from E. coli)

Rat Recombinant IL-17A (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins. IL-17A is a proinflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes. IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion. In turn, the cytokines and chemokines mediate the immunoregulatory function of IL-17A by promoting the proliferation, maturation, and chemoattraction of neutrophils to inflammatory sites.  Elevated levels of IL-17A are associated with rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer, and multiple sclerosis.  Human, mouse, and rat IL-17A show activity on mouse cells.  

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Mouse Recombinant IL-2 (from E. coli)

Mouse Recombinant IL-2 (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes.  IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.

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Rat Recombinant IL-6 (Animal free) (from E. coli)

Rat Recombinant IL-6 (Animal free) (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Leptin is a hormone that is produced by adipose tissue and plays critical roles in the physiologic regulation of body weight. Leptin acts through the leptin receptor (LEPR) to regulate adipose mass by inhibiting hunger and balancing energy usage. Leptin mutations cause severe hereditary obesity and hypogonadism in rodents and humans. Leptin also has thermogenic actions, regulates enzymes of fatty acid oxidation, and is involved in hematopoiesis, angiogenesis, wound healing, inflammation, and immune responses.

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Mouse Recombinant Rank Ligand (from E. coli)

Mouse Recombinant Rank Ligand (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Receptor activator of nuclear factor kappa-B Ligand (RANK Ligand) is a cell-bound marker related to the tumor necrosis factor (TNF) family of proteins. RANK Ligand plays a critical role in bone metabolism and osteoclast differentiation. T cell expression of RANK Ligand promotes dendritic cell maturation.

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Rat Recombinant M-CSF (from E. coli)

Rat Recombinant M-CSF (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Macrophage colony stimulating factor (M-CSF) is a hematopoietic growth factor that is widely produced by a variety of cells. M-CSF stimulates the proliferation and differentiation of hematopoietic stem cells into monocyte and macrophage cell types. M-CSF also acts through the colony stimulating factor 1 receptor (CSF1R) to modulate processes involved in immunology, bone metabolism, fertility, and pregnancy.

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Human Recombinant EGF (from E. coli)

Human Recombinant EGF (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Epidermal growth factor (EGF) is a growth factor that stimulates the proliferation, differentiation, and survival of epithelial and epidermal cells. EGF contains three intramolecular disulfide bonds and binds in high affinity to the epidermal growth factor receptor (EGFR). EGF is overexpressed in multiple tumor cell lines and promotes resistance to chemotherapy and radiation treatments.

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Human Recombinant Procalcitonin (from E. coli)

Human Recombinant Procalcitonin (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Procalcitonin is a precursor of the peptide hormone calcitonin. Procalcitonin is mainly produced by the neuroendocrine cells of the lung and thyroid gland, but may be secreted ubiquitously during inflammation or infection. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments: calcitonin, katacalcin, and an N terminal residue. Levels of unprocessed procalcitonin are significantly increased after bacterial infection, inflammation, trauma, or shock.

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Human Recombinant EG-VEGF (from E. coli)

Human Recombinant EG-VEGF (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is an angiogenic growth factor that is expressed in the ovaries, testis, adrenal, and placental tissues. EG-VEGF has mitogenic, chemoattractive, and antiapoptotic functional roles.

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Rat Recombinant LEPTIN (from E. coli)

Rat Recombinant LEPTIN (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Macrophage inflammatory protein-1 alpha (MIP-1 α), also known as CCL3, is a cytokine produced by macrophages. MIP-1 α binds the chemokine receptors CCR1, CCR4 and CCR5 to induce inflammatory responses, including the recruitment of granulocytes and neutrophil superoxide production. The MIP-1 α and MIP-1 β heterodimer exhibits antiviral activity against the human immunodeficiency virus 1 (HIV-1).

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Mouse Recombinant Leptin (from E. coli)

Mouse Recombinant Leptin (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Leptin is a hormone that is produced by adipose tissue and plays critical roles in the physiologic regulation of body weight. Leptin acts through the leptin receptor (LEPR) to regulate adipose mass by inhibiting hunger and balancing energy usage. Leptin mutations cause severe hereditary obesity and hypogonadism in rodents and humans. Leptin also has thermogenic actions, regulates enzymes of fatty acid oxidation, and is involved in hematopoiesis, angiogenesis, wound healing, inflammation, and immune responses.

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Mouse Recombinant IP-10  (from E. coli)

Mouse Recombinant IP-10 (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Macrophage inflammatory protein-1 alpha (MIP-1 α), also known as CCL3, is a cytokine produced by macrophages. MIP-1 α binds the chemokine receptors CCR1, CCR4, and CCR5 to induce inflammatory responses, including the recruitment of granulocytes and neutrophil superoxide production. The MIP-1 α and MIP-1 β heterodimer exhibits antiviral activity against the human immunodeficiency virus 1 (HIV-1).

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Rat Recombinant IL-17F (from E. coli)

Rat Recombinant IL-17F (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Vascular endothelial growth factor-A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several alternatively spliced isoforms, with VEGF-165 being the most abundant. The VEGF-165 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell proliferation and angiogenesis.

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Mouse Recombinant IL-33 (Animal free) (from E. coli)

Mouse Recombinant IL-33 (Animal free) (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Interleukin 33 (IL-33) is a member of the IL-1 cytokine family and is constitutively expressed in smooth muscle and airway epithelial cells. IL-33 signals through the interleukin 1 receptor-like 1 (IL-1R1) and interleukin-1 receptor accessory protein (IL1RAP) receptors to ativate NF-κB and MAPK signaling pathways. IL-33 functions to induce type 2 cytokine production in polarized Type 2 helper T (Th2) cells.

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Mouse Recombinant IL-27/P28 (from E. coli)

Mouse Recombinant IL-27/P28 (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

The p28 subunit of interleukin 27 (IL-27), also known as interleukin 30 (IL-30), is a member of the interleukin 12 (IL-12) family of cytokines. p28 is a secreted polypeptide that associates with the Epstein-Barr virus induced gene 3 (EBI3) to form the IL-27 cytokine heterodimer complex. IL-27 functions as a proinflammatory cytokine that induces immunomodulatory effects in naïve CD4+ T cells, mast cells, and monocytes. p28 can also form a complex with cytokine-like factor 1 (CLF), that is secreted by dendritic cells, to regulate natural killer (NK) and T cell functions.

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Human Recombinant IL-32alpha (from E. coli)

Human Recombinant IL-32alpha (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Interleukin 32 alpha (IL-32a) is one of six known splice variants of the IL-32 gene.  IL-32a induces the macrophage production of inflammatory cytokines, such as interleukin 8 (IL-8), tumor necrosis factor-alpha (TNF-a), and macrophage inflammatory protein 2 (MIP2).  IL-32a expression is increased after the activation of T cells, natural killer (NK) cells, and interferon gamma-treated epithelial cells.

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Human Recombinant Oncostatin M (from E. coli)

Human Recombinant Oncostatin M (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Oncostatin M is a cytokine that is produced by macrophages, dendritic cells, and T lymphocytes during inflammatory events. The Type-I and Type-II Oncostatin M receptors are located on the cell surface of endothelial and tumor cells, contain the glycoprotein 130 (gp130) subunit, and activate the JAK/STAT signaling pathway. Oncostatin M functions to inhibit tumor cell proliferation, induce liver stem cell maturation, regulate cytokine production during hematopoiesis and inflammation, stimulate bone formation, and promote nervous system development.

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Human Recombinant SDF-1 A/CXCL12 (from E. coli)

Human Recombinant SDF-1 A/CXCL12 (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Interleukin 31 (IL-31) is an immunoregulatory cytokine that is expressed by activated type 2 T helper (Th2) cells. IL-31 signals through a heterodimer receptor consisting of the IL-31 Receptor A (IL-31RA) and the oncostatin M receptor (OSMR), which are expressed on monocytes, epithelial cells, and keratinocytes. IL-31 promotes allergic reactions and inflammatory skin diseases.

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Human Recombinant RH HB-EGF (Animal free) (from E. coli)

Human Recombinant RH HB-EGF (Animal free) (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the epidermal growth factor (EGF) family and is expressed by monocytes and macrophages. HB-EGF is the predominant growth factor involved in epithelialization during wound healing. HB-EGF signals through the receptor tyrosine kinase ErbB2 to maintain adult heart homeostasis, and promotes cardiac valve development through binding in high affinity to the epidermal growth factor receptor (EGFR). HB-EGF binds the the ErbB4 receptor tyrosine kinase to mediate implantation of the human blastocyst. HB-EGF also functions as a potent mitogen for fibroblasts and smooth muscle cells.

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Rat Recombinant IL-10 (from E. coli)

Rat Recombinant IL-10 (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Interleukin 10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. IL-10 inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFN-ƴ), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells.

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Pig Recombinant IL-8 (from E. coli)

Pig Recombinant IL-8 (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Interleukin 8 (IL-8 or CXCL8) is a member of the CXC cytokine family and is produced by macrophages, epithelial, smooth muscle, and endothelial cells. IL-8 binds the  G protein-coupled serpentine receptors CXCR1 and CXCR2. IL-8 recruits innate immune cells, induces phagocytosis, and stimulates angiogenesis.

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Pig Recombinant IL2 (from E. coli)

Pig Recombinant IL2 (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes. IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.

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Rat Recombinant VEGF-165 (Animal free) (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Interleukin 10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. IL-10 inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFN-ƴ), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells.

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Human Th9 Cell Polarizing Recombinant Protein Bundle (rh IL-4, rh TGF-β 1)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Cytokines for mouse neuronal cell culture. Neural Stem Cells (NSC) are self-renewing cells, of the neural lineage, capable of generating neurons (GABA, dopamine and motor neurons), astrocytes and oligodenrocytes. NSCs are marked by expression of Nestin and can be derived from fetal neural stem cells, adult neural stem cells, embryonic stem cells and adult somatic cells.

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Mouse Th9 Cell Polarizing Recombinant Protein Bundle (rm IL-4, rh TGF-β 1) (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Cytokines for polarizing mouse T cells into Th9 cells. Th9 cells are a unique subset of T helper cells that produce IL-9. Although the exact function of IL-9 producing T cells is yet to be completely clear it is proposed that these cells could be important in inflammation and helminth infections. Th9 cells can be generated from naive CD4+ T cells in culture by culturing them in the presence of IL-4 and TGF-β 1. It also appears that IFNγ and IL-27 can inhibit the generation of Th9 cells.

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Human Recombinant Amphiregulin (Animal Free) (from E. coli)

Human Recombinant Amphiregulin (Animal Free) (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Amphiregulin (AR) is a member of the epidermal growth factor (EGF) family. AR is an autocrine growth factor and functions to regulate cell proliferation and survival through binding the EGF receptor (EGFR). AR promotes the proliferation of neural stem cells and epithelial cells, including keratinocytes and mammary epithelium. Up-regulated at puberty, AR promotes ductal outgrowth and mammary branching. In the liver, AR functions as a mitogen and prevents hepatocyte apoptosis. In a cancer context, AR protects against human adenocarcinoma apoptosis, promotes tumor cell growth, and functions as an oncogenic factor in the Hippo pathway. AR levels are increased in the brain following stress events, such as inflammation, ischemia, and hypoxia.

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Human Recombinant IL-1RA (Animal free) (from E. coli)

Human Recombinant IL-1RA (Animal free) (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Receptor activator of nuclear factor kappa-B Ligand (RANK Ligand) is a cell-bound marker related to the tumor necrosis factor (TNF) family of proteins. RANK Ligand plays a critical role in bone metabolism and osteoclast differentiation. T cell expression of RANK Ligand promotes dendritic cell maturation.

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Human Recombinant FGF-5 (Animal Free) (from E. coli)

Human Recombinant FGF-5 (Animal Free) (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

Fibroblast growth factor 5 (FGF-5) is a secreted heparin-binding growth factor that binds to FGF receptors 1 and 2 (FGFR1 and FGFR2). FGF-5 is expressed in the mesenchyme, skeletal muscles, central nervous system, and hair follicles to promote cell differentiation and proliferation. FGF-5 functions as a regulatory factor during hair elongation and skeletal muscle development.

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