11486 Results for: "Enzo Life Sciences"

Supplier: Enzo Life Sciences

A DNA-intercalating antitumor agent. Inhibits DNA topoisomerase II. Inhibits the phosphorylation of p53 in Lewis lung carcinoma cells and induces apoptosis. Inhibits cytochrome P-450-1A1.

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG2a

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG2a

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG3

Supplier: Enzo Life Sciences

Potent inhibitor of histone deacetylases (HDACs) (IC50≤1µM).

Supplier: Enzo Life Sciences

Inhibitor of ornithine decarboxylase and arginase

Supplier: Enzo Life Sciences

Mammalian apurinic/apyrimidinic (AP) endonuclease (APE1; APEX; HAP1; Ref-1) is a multifunctional, bipartite enzyme that belongs to the class II AP endonucleases and that plays an important role in numerous, cellular functions, like repairing abasic sites (loss of purine or pyrimidine base) in DNA, regulating the redox state of other proteins that play roles in oxidative signalling, transcription factor regulation (Fos, Jun, NF-κ B, Myb, HIF-1α, CREB, Pac), cell cycle control (p53) and apoptosis. APE1 initiates the DNA base excision repair (BER) by cleaving the DNA immediately adjacent to the 5’ of an AP site to produce a hydroxyl group at the 3’ terminus of an unmodified nucleotide upstream of the nick and a 5’-deoxyribose phosphate moiety downstream. The product of APE1 is further processed by DNA polymerase β to release 5’-deoxyribose phosphate with its intrinsic lyase activity. The nicked DNA is then sealed by DNA ligase I or DNA ligaseIII/XRCC1 to complete this repair process. In addition to the AP endonuclease activity, APE1 also possesses a 3’-5’ DNA exonuclease activity, a 3’-phosphodiesterase activity, a 3’-phosphatase activity, and a RNase H activity. It has been shown that APE1 is capable of excision L-configuration deoxyribonucleoside analogs from the 3’ termini of DNA. Human APE1 gene is located on chromosome 14q 11.2-12.

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgM

Supplier: Enzo Life Sciences

PARP-1 inhibitor

Supplier: Enzo Life Sciences

Potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor (IC50=450nM). Neuroprotectant.

Supplier: Enzo Life Sciences

Represents a class of natural compounds, which inhibit proliferation in eukaryotes by blocking nuclear export. As potent as leptomycin B (Prod. No. ALX-380-100) and specific for G1/S checkpoint. Cytotoxic secondary metabolite (IC50=50pg/ml in mouse cell line L929) that arrests tumor cells in the G1 phase at remarkably low concentrations (50pg/ml in HeLa cell line KB3.1). Inhibits the binding between the nuclear export signal (NES) of proteins and the chromosome maintenance region protein (CRM1). Anticancer compound. Belongs to the family of orphan ligands which include polyketides like leptomycin B, callystatin A and other related compounds.

Supplier: Enzo Life Sciences

MDA5 is a highly conserved helicase whose ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. The helicase domain, once freed from the CARD domains, then translocates from the cytoplasm to the nucleus where it acts on chromatin architecture. This could allow a more easy access of CAD, thereby accelerating the degradation of genomic DNA.

Supplier: Enzo Life Sciences

The assay is designed to detect ADP/ATP ratio. The changes in ADP/ATP ratios have been used to conveniently differentiate apoptosis from necrosis.

Supplier: Enzo Life Sciences

The SCREEN-WELL® Nuclear Receptor Ligand Library contains 74 compounds with defined, putative and potential activity at nuclear receptors.

Supplier: Enzo Life Sciences

Protease inhibitor

Supplier: Enzo Life Sciences

Substrate for caspase-1 and -4

Supplier: Enzo Life Sciences

Caspase-9 substrate

Supplier: Enzo Life Sciences

Caspase-4 substrate

Supplier: Enzo Life Sciences

Colorimetric caspase substrate for caspase-1, -4, -5 and -14.

Supplier: Enzo Life Sciences

Inhibitor of caspase-1 and -4

Supplier: Enzo Life Sciences

The DPPIV Drug Discovery Kit is a complete assay system designed to screen DPPIV inhibitors, a potential therapeutic target, providing enough material to perform at least 96 assays.

Supplier: Enzo Life Sciences

Nitric oxide (NO) donor.

Supplier: Enzo Life Sciences

Stable nitric oxide (NO) radical scavenger.

Supplier: Enzo Life Sciences

Circulating metabolite of PGE1 in man. Vasodilator equipotent with PGE12. Inhibits human platelet aggregation. Antimitotic activity.

Supplier: Enzo Life Sciences

Produced in HEK 293 cells. The cysteine-rich domain of human NGFR (nerve growth factor receptor; p75NTR) (aa 1-250) is fused to the Fc portion of human IgG1.

Supplier: Enzo Life Sciences

Produced in HEK 293 cells. The extracellular domain of mouse Thy-1 (aa 20-131) is fused to the Fc portion of human IgG1.

Supplier: Enzo Life Sciences

Produced in E. coli. Human IL-1β (interleukin-1β) (aa 117-270) is fused to a linker peptide (10 aa) and an N-terminal FLAG®-tag.

Supplier: Enzo Life Sciences

Produced in HEK 293 cells. The extracellular domain of human CD40L (CD154) (aa 116-261) is fused at the N-terminus to the Fc portion of human IgG1 and a linker peptide (20 aa).

Supplier: Enzo Life Sciences

Dihydrofolate reductase inhibitor

Supplier: Enzo Life Sciences

Selective and cell permeable inhibitor of the interaction between the human eukaryotic translation initiation factors 4E (eIF4E) and 4G (eIF4G).