69 Results for: "BioVendor"

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beta-Lactamase (from E. coli)

Supplier: BioVendor

Beta-lactamase is a type of enzyme (EC 3.5.2.6) produced by some bacteria that is responsible for their resistance to beta-lactam antibiotics like penicillins, cephalosporins, cephamycins and carbapenems

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Human Rhu Fgf-21 (fromE. coli)

Supplier: BioVendor

The FGFs are a family of more than 20 small (~17–26 kDa) secreted peptides. The initial characterization of these proteins focused on their ability to stimulate fibroblast proliferation. This mitogenic activity was mediated through FGF receptors (FGFRs) 1, 2, or 3. A fourth closely related tyrosine kinase receptor (FGFR4) was able to bind the FGFs but did not lead to a mitogenic response.

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Human Recombinant Cyclophilin B (from E. coli)

Supplier: BioVendor

Cyclophilins facilitate the process of protein folding. They catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin B is located in endoplasmic reticulum lumen. It is inhibited by an immunosuppressant cyclosporin.

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GP96 (HSP90B1) Human HEK293, 0.1 mg

Supplier: BioVendor

Total 789 AA. MW: 90.9 kDa (calculated). UniProtKB acc. No. Q5CAQ5 (Asp22–Glu798). N-terminal linker (2 extra AA), C-terminal linker (4 extra AA) and C-terminal His-tag (6 extra AA). Protein identity confirmed by LC-MS/MS.

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Human Recombinant CRISP2 (from E. coli)

Supplier: BioVendor

Recombinant protein contains amino acids no. 22–243 of the protein acc.no. P16562 in UniProtKB. Total 232 AA. MW: 26.32 kDa (calculated). N-Terminal His-tag (10 extra AA)

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Human Rhu Srage (soluble) (fromE. coli)

Supplier: BioVendor

The receptor for advanced glycation end products (RAGE) is a multiligand member of the immunoglobulin superfamily of cell surface molecules. It mediates interactions of advanced glycation end products (AGE), the products of nonenzymatic glycoxidation of proteins/lipids that accumulate in the plasma and tissues of patients with diabetes.

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Endo Trap® HD Leakage ELISA, Biovendor

Supplier: BioVendor

96 wells (1 kit) - ELISA is a competitive enzyme immunoassay for the quantitative measurement of endotoxin.

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Human Recombinant Cyclophilin F (from E. coli)

Supplier: BioVendor

Cyclophilins facilitate the process of protein folding. They catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin F is located in mitochondrion matrix. Cyclophilin F is involved in regulation of the mitochondrial permeability transition pore. It may activate or inhibit apoptosis or necrosis. It binds to an immunosuppressant cyclosporin.

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Mouse RCystatin C (from E. coli)

Supplier: BioVendor

Cystatin C is a non-glycosilated basic single-chain protein consisting of 120 amino acids with a molecular weight of 13.36 kDa and is characterized by two disulfide bonds in the carboxy-terminal region. It belongs to the cystatins superfamilly which inactivates lysosomal cysteine proteinases, e.g. cathepsin B, H,.K, L and S. Imbalance between Cystatin C and cysteine proteinases is associated with inflammation, renal failure, cancer, Alzheimer's disease, multiple sclerosis and hereditary Cystatin C amyloid angiopathy. Its increased level has been found in patients with autoimune diseases, with colorectal tumors and in patients on dyalisis. Serum Cystatin C seems to be better marker of glomerular filtration rate than creatinine. On the other hand, low concentration of Cystatin C presents a risk factor for secondary cardiovascular events.

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Human Recombinant BTP (from E. coli)

Supplier: BioVendor

BTP catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.

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Human Rhu Pedf (fromE. coli)

Supplier: BioVendor

Interactions of PEDF with three different types of molecules have been discovered: glycosaminoglycans of extracellular matrixes, collagens and receptors on the surface of neuronal cells. Negatively charged, acidic PEDF binds to collagen, lacks neurotrophic activity, and may confer antiangiogenic properties. PEDF has gliastatic, neuronotrophic, neuroprotective and antitumorigenic properties. PEDF acts in neuronal differentiation and survival in cells derived from retina and the central nervous system .

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Human Native Rhu alpha-2 Microglobulin (from Plasma)

Supplier: BioVendor

Alpha-2 Macroglobulin is a serine proteases inhibitor, which inhibits coagulation by inactivating thrombin and Kallikrein, it inhibits fibrinolysis by inactivating plasmin and involved in insulin transport. Alpha-2-Macroglobulin is a large plasma protein, which is produced by the liver, it’s composed of 4 identical subunits bound together by -S-S- bonds. A2M is able to inactivate many kinds of proteinases (including serine-, cysteine-, aspartic- and metalloproteinases). A2M has a 35 amino acid "bait" region in its structure. Proteinases bind and cleave the “bait” region become bound to A2M. Macrophage receptors recognize the proteinase-A2M complex and clear it from the system. A2M binds to and removes MMP-2 and MMP-9 (active forms of the gelatinase) from the circulation using scavenger receptors on the phagocytes. The levels of Alpha-2-macroglobulin are increased in nephrotic syndrome which is a condition where the kidneys start to leak out some of the smaller blood proteins. Due to its large size, A2-macroglobulin is retained in the bloodstream. Increased production of all proteins causes A2-macroglobulin concentration to increase. Chronic renal failure might lead to amyloid by alpha-2-macroglobulin. A2M is raised in cirrhosis, pregnancy and diabetes.

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Human Recombinant ANGPTL6 (from E. coli)

Supplier: BioVendor

Seven angiopoietin-like proteins (ANGPTLs) share the char-acteristic protein structure of the angiopoietin family (ANG), but differ in their inability to bind antiopoietin receptor, Tie-2. ANGPTL6 was originally named angiopoietin-related growth factor (AGF) having an N-terminal coiled-coil-like domain and a C-terminal fibrinogen-like domain, both of which are conserved in ANG. It is a circulating protein secreted by liver that induces angiogenesis by direct effect of epidermal ANGPTL6 on endothelial cells and proliferation of skin cells, and thereby promotes wound healing.

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Human Recombinant CRISP3 (from E. coli)

Supplier: BioVendor

Cysteine-rich secretory protein 3 (CRISP-3, SGP 28) belongs to the CRISP family of proteins having a PR-1 (pathogenesis related protein 1) domain at its N-terminal and ion channel regulatory (ICR) domain at its C-terminal connected by a hinge region. CRISP-3 transcripts are shown to be present predominantly in the prostate. Its expression is low in benign prostatic epithelium but is highly upregulated in the majority of high-grade prostatic intraepithelial neoplasia lesions and in most primary prostate tumours and metastases. Two independent studies have shown that CRISP-3 is one of the genes that are most often upregulated in prostate cancer. Human Prostate Secretory Protein (PSP94) has been shown to bind human CRISP-3 with very high affinity. Functional significance of this complex is not yet known. Yet, it was suggested, that involvement of the hinge region of CRISPs in interaction with PSP94 may affect the domain movement of CRISPs essential for the ion-channel regulatory activity resulting in inhibition of this activity.

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Rat/Mouse PINP EIA, BioVendor

Supplier: BioVendor

96 wells (1 kit) - ELISA is a competitive enzyme immunoassay for the quantitative measurement of PINP.

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Human Recombinant Cidec (from E. coli)

Supplier: BioVendor

Cell death activator CIDE-3 regulates enlargement of lipid droplets. It is expressed mainly in adipocytes, intestine, heart, stomach, and weakly in brain, kidney and liver. Its overexpression in preadipocytes induces apoptosis.