1874 Results for: "Anaspec Inc"

Supplier: Anaspec Inc

This is amino acids 79 to 87 fragment of shepherdin, a novel peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability. For its potent and broad antitumor activity, selectivity of action in tumor cells versus normal tissues, and inhibition of tumor growth in vivo without toxicity, shepherdin may offer a promising approach for rational cancer therapy. This sequence is also known as K79–K90.
Sequence:KHSSGCAFL
MW:949.1 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

This peptide corresponds to residues 206–214 of murine islet-specific glucose-6-phosphatase catalytic subunit–related protein (IGRP). This peptide is T cells specific for proinsulin and IGRP induces diabetes in non-obese diabetic (NOD) mice.
Sequence: VYLKTNVFL
MW: 1096.3 Da
% Peak area by HPLC: 95
Storage condition: -20° C

Supplier: Anaspec Inc

This is a hexapeptide with 6 histidines primarily used in tagging proteins. His tags have been used in affinity purification of recombinant proteins and have also been used in studying protein transduction in cells with the use of cell-penetrating proteins/peptides.
Sequence:HHHHHH
MW:841.9 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

This peptide is beta-amyloid (1-38) with phenylalanine and isoleucine universally labeled with 13C. Ab is found in amyloid deposits of Alzheimer’s patients and is implicated in the pathogenesis of this disease.
Sequence: DAEFRHDSGYEVHHQKLV-*F-*F-AEDVGSNKGA-*I-*I-GLMVGG *F=Phe(U-13C9), *I=Ile(U-13C6)
Molecular Weight: 4161.6 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

Supplier: Anaspec Inc

R-Phycoerythrin (R-PE), a fluorescent protein from phycobiliprotein family, is isolated from red algae. Its primary absorption peak is at 565 nm with secondary peaks at 496 and 545 nm. The broad excitation spectrum provides the advantage for multi-color immunofluorescent staining or cell sorting. R-PE consists of a, b and g subunits and is present as (ab)6g. R-PE and the closely related BPE are the most intensely fluorescent phycobiliproteins having orange fluorescence. They are significantly brighter and more photostable than conventional organic fluorophores.

Supplier: Anaspec Inc

This NDP-MSH peptide is fluorescently (5-TAMRA)-labeled on the N-terminus. Abs/Em=544/572 nm. NDP-MSH is a synthetic analog of alpha-Melanotropin (alpha-MSH, alpha-melanocyte-stimulating hormone) in which Asp4 has been replaced with Norleucine and L-Phe with the D-isomer of Phe [Nle4D-Phe7] (NDP). NDP-MSH is a more potent in increasing pigmentation and decreasing UV damage in fair-skinned Caucasian volunteers.
Sequence: 5-TMR-SYS-Nle-EHfRWGKPV-NH2
MW: 2017.3 Da
% Peak area by HPLC: 95
Storage condition: -20° C

Supplier: Anaspec Inc

This peptide, derived from the latency-associated peptide, inhibits thrombospondin (TSP-1) activation of TGF-ß; thus preventing the progression of hepatic damage and fibrosis.
Sequence:LSKL-NH2
MW:458.6 Da
%Peak area by HPLC:≥95%
Storage condition: -20°C

Supplier: Anaspec Inc

This peptide is derived from Histone H3 1-21 amino acids, and is usually used as a substrate for methylation and acetylation assays.
Sequence:ARTKQTARKSTGGKAPRKQLA
MW:2254.6 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

HiLyte™ Fluor 532 amine is a carbonyl-reactive fluorescent labeling dye.

Supplier: Anaspec Inc

AMCA-X, SE is one of the most popular blue fluorescent tagging molecules. It is widely used to label antibodies, proteins and small drug molecules. AMCA-X succinimidyl ester contains a seven-atom aminohexanoyl spacer, the so-called ‘X’ spacer, between the fluorophore and the reactive group. It is well known that the spacer between the fluorophore and the reactive group usually separates the fluorophore from the biomolecule to which it is conjugated, potentially reducing the quenching that typically occurs upon conjugation. In some cases, the ‘X’ spacer allows the dye to be more available for recognition by secondary detection reagents.

Supplier: Anaspec Inc

This 29 amino acid sheep myeloid antimicrobial peptide 29 (SMAP 29) displays extremely high antimicrobial activity against Pseudomonas strains, other gram-negative bacteria, and multidrug-resistant pathogens. SMAP 29 is a broad-spectrum antibiotic cathelicidin, it is active in both low- and high-ionic-strength conditions, and induces significant morphological alterations in bacterial surfaces.
Sequence:RGLRRLGRKIAHGVKKYGPTVLRIIRIAG
MW:3256 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

FRETS-VWF73 is a very powerful Fluorescence-Quenching Substrate for the VWF cleaving protease ADAMTS-13. It is commonly used as a useful tool for the rapid measurement of ADAMTS-13 activity in plasma and is a predictive marker for various thrombotic diseases like TPP. Our new substrate FRETS-VWF73 can be easily used with a 96-well format in commercial plate readers.
Sequence: DRE-Dap(Nma)-APNLVYMVTG-Dpa-PASDEIKRLPGDIQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQR
MW: 8314.3 Da
% Peak Area by HPLC: ≥ 95%
Storage condition: -20°C

Supplier: Anaspec Inc

Caspase 1 Inhibitor II is an irreversible caspase-1, (IL-1β-converting enzyme, ICE) inhibitor. It is neuroprotective, rescuing neuronal cell cultures from cell death. It alco reduces lipopolysaccharide-lethality in animals.
Sequence:Ac-YVAD-CMK
MW:541 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

This peptide is derived from thrombospondin and represents a binding motif responsible for thrombospondin-CD36 interaction. It is cyclized through a disulfide bond. Thrombospondin is a matrix-bound glycoprotein involved in cancer metastasis, tumor adhesion, and angiogenesis. This peptide has been shown to competitively inhibit platelet aggregation and tumor metastasis.
Sequence:CSVTCG (S-S Bonded)
MW:566.7 Da
%Peak area by HPLC:≥95%
Storage condition: -20°C

Supplier: Anaspec Inc

This peptide corresponds to the GAP27 domain of the second extracellular loop of dominant vascular connexin (Cx40), designated as 40Gap 27. It was used to investigate mechanisms through which oxidant stress impairs communication via gap junctions. When administered, 40Gap27 attenuates endothelium-dependent subintimal smooth muscle hyperpolarization.
Sequence:SRPTEKNVFIV
MW:1289.5 Da
%Peak area by HPLC:≥95%
Storage condition: -20°C

Supplier: Anaspec Inc

This T-cell epitope WMHHNMDLI is a male-specific transplantation antigen, H-Y, derived from mouse UTY (ubiquitously transcribed tetratricopeptide repeat gene on the Y chromosome) protein. It is presented by H2-Db
Sequence:WMHHNMDLI
MW:1196.4 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

This sequence is the hallmark of MUC1 mucin. MUC1 is a highly glycosylated type I transmembrane glycoprotein with a unique extracellular domain consisting of a variable number of tandem repeats (VNTR) of this 20 amino acid peptide It is overexpressed on the cell surface of many human adenocarcinomas and hematological malignancies, including multiple myeloma and B-cell lymphoma, making MUC1 broadly applicable target for immunotherapeutic strategies
Sequence:PDTRPAPGSTAPPAHGVTSA
MW:1887 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

The unlabeled phosphopeptide is an excellent substrate for mammalian protein tyrosine phosphatase 1B (Km = 3.9 µM) and Yersinia PTP. The sequence is derived from an autophosphorylation site (Tyr992) of EGFR. The unlabeled peptide is used to assay PTB based on marked fluorescence increase upon the removal of the phosphate group (Em = 305 nm and Ex = 282 nm).
Sequence:5-FAM-DADE-pY-LIPQQG
MW:1686.6 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

This is the immunodominant epitope gB-8p from herpes simplex virus (HSV) glycoprotein B (gB), amino acids 498 to 505.
Sequence:SSIEFARL
MW:922.1 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKgammaNEMO with the IKK complex is critical for the activation of the IKK complex and the subsequent activation of NF-kB.
Sequence:DRQIKIWFQNRRMKWKKTALDWSWLQTE
MW:3693.3 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

Compared to the 5-isomer, tetramethylrhodamine-6-maleimide is preferably used for thiol modifications of nucleotides and nucleic acids.

Supplier: Anaspec Inc

Luteinizing Hormone-Releasing Hormone (LHRH), also known as GnRH or FSH-RH, is a hypothalamic hormone that controls the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the pituitary gland and promotes mating behavior. It stimulates the secretion of gonadotropins after its interaction with specific G-protein-coupled receptors that are present in plasma membranes of pituitary gonadotrophs. In addition to hypophysiotropic effect, it also plays a autocrine/paracrine role in peripheral organs such as prostate, breast and ovary. LHRH is not only a neurohormone but may also function as a neurotransmitter or neuromodulator. It also has a role in angiogenesis, cell proliferation, and tumor metastasis.
Sequence:Pyr-HWSYGLRPG-NH2
MW:1182.3 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

Enkephalins are pentapeptides involved in regulating nociception in the body. There are two enkephalin forms, one containing leucine and the other containing methionine ("met"). Both are products of the proenkephalin gene.
Sequence:YGGFM
MW:573.8 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

This 13 amino acid peptide was first isolated from bovine hypothalamus and was named from its neuronal localization. It was detected in the central nervous system (CNS) and peripheral tissues mainly in the gastrointestinal tract. This bioactive form of neurotensin post-translationally modified at a Glu residue was isolated from porcine intestine.
Sequence:pE-LYENKPRRPYIL
MW:1672.92 Da
%Peak area by HPLC:≥95%
Storage condition: -20°C

Supplier: Anaspec Inc

A glutathione-derived heavy metal-detoxifying peptide of higher plants consisting of 3 units of gammaGlu-Cys.
Sequence:(γE-C)3-G
MW:772.9 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

Secretin, a 27-amino acid gastrointestinal peptide hormone, has been implicated in numerous regulatory events involving the pancreas, biliary tree, stomach, nerves and kidney. It is relatively conserved through evolution. Rat secretin differs from its porcine counterpart by a single glutamine-for-arginine substitution at position 14.
Sequence: HSDGTFTSELSRLQDSARLQRLLQGLV-NH2
MW: 3028.7 Da
% Peak area by HPLC: 95
Storage condition: -20° C

Supplier: Anaspec Inc

HLA-A11 restricted epitope from Epstein-Barr Virus BRLF1 (134-142).
Sequence: ATIGTAMYK
MW: 955.2 Da
% Peak area by HPLC: 95
Storage condition: -20°C

Supplier: Anaspec Inc

A substrate for DNA-dependent protein kinase (DNA-PK), phosphorylation. DNA-PK is essential for the repair of DNA double-strand breaks. This peptide corresponding to 11–24 amino acids of human p53 with threonine 18 and serine 20 changed to alanine is used as a substrate for the assay of DNA-PK activity
Sequence:EPPLSQEAFADLWKK
MW:1759 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

This is TAMRA-labeled Abltide (Ab/Em = 544/572 nm). Abltide is a peptide substrate for Abl Kinase (Abl protein tyrosine kinase), a partner in the gag-Abl fusion protein of the Abelson murine leukemia virus. Used in Western blot and kinase assays.
Sequence:5-TAMRA-KKGEAIYAAPFA-NH2
MW:1677 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

Proinsulin C-peptide is the sequence of C peptide as it exists within proinsulin, the precursor to insulin which consists of insulin A chain, insulin B chain and C peptide (connecting peptide). In proinsulin, C peptide provides a means to ensure correct folding and assembly of the A and B chains. It is eventually cleaved away by proteases PC2, PC1/3 and CPE, at the flanking Arg-Arg and Lys-Arg basic residues (Arg-Arg-C peptide-Lys-Arg). Although C peptide is not present in mature insulin, it is stored in secretory granules, and eventually released into the bloodstream together with insulin in nearly equimolar amounts. Whereas insulin is metabolized quickly from circulation, C-peptide exhibits a slow turnover rate (>30 minutes). The measurement of the C-peptide is an important test for the β-cell function. In the red blood cells of type 2 diabetic patients, Na+,K+, ATPase activity is strongly related to blood C-peptide levels. C-peptide signal transduction in human renal tubular cells involves the activation of phospholipase C and PKC-δ and PKC-varepsilon, as well as RhoA, followed by phosphorylation of ERK1/2 and JNK and a parallel activation of Akt. C-peptide shows specific binding to a G-protein-coupled membrane binding site, resulting in Ca2+ influx, activation of mitogen-activated protein kinase signalling pathways and stimulation of Na+, K+ ATPase and endothelial nitric oxide synthase.
Sequence: RREAENPQAGAVELGGGLGGLQALALEGPPQKR
MW: 3340.7 Da
% Peak area by HPLC: 95
Storage condition: -20° C