1874 Results for: "Anaspec Inc"

Supplier: Anaspec Inc

KALA is a cationic amphipathic cell-penetrating peptide (CPP). It assumes an alpha-helix conformation when the pH is 7.5. KALA binds oligonucleotides and disrupts cell membrane; therefore, it can be used as a DNA transfection reagent.
Sequence:WEAKLAKALAKALAKHLAKALAKALKACEA
MW:3131.8 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

Magainins are peptide antibiotics with antibacterial and antiparasitic activities, originally extracted from the skin of Xenopus laevis. Magainin 1 and 2 are closely related peptides of 23 amino acids each and differ by two substitutions. These antimicrobial peptides have broad-spectrum, non-specific activity against a wide range of micro-organisms, including viruses, gram-positive and gram-negative bacteria, protozoa, yeasts and fungi, and may also be hemolytic and cytotoxic to cancer cells. Magainin 1 is a bactericide. Both Magainin 1 and 2 exhibit inhibitory action toward Herpes simplex virus type 1(HSV-1) and HSV-2.
Sequence:GIGKFLHSAGKFGKAFVGEIMKS
MW:2409.9 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

This is a phosphorylated PKC substrate-3 peptide.
Sequence:KRP-pS-QRHGSKY-NH2
MW:1422.5 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

HiLyte™ Fluor 488, SE is an excellent amine-reactive fluorescent labeling dye for generating protein conjugates. The spectrum of HiLyte™ Fluor488 is similar to fluorescein (FITC), resulting in an optimal match to filters designed for fluorescein.

Supplier: Anaspec Inc

Renin, a highly specific aspartyl protease, cleaves angiotensinogen, produced in the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE (Angiotensin Converting Enzyme). Angiotensin II constricts blood vessels, leading to increased blood pressure. It also increases the secretion of ADH and aldosterone, and stimulates the hypothalamus to activate the thirst reflex. Since an overactive renin-angiotensin system leads to hypertension, renin is proposed as a therapeutic target for this disease

The recombinant human pro-renin was expressed in HEK cells and converted to the active renin. After affinity chromatography, the active enzyme has a purity of >99% by SDS-PAGE. The molecular mass of active human renin is approximately 40 kDa.
The activity of enzyme can be measured in FRET-based assays

Supplier: Anaspec Inc

HiLyte™ Fluor 555 acid, SE is an excellent amine-reactive fluorescent labeling dye that generates the protein conjugates that are only slightly red-shifted compared to those of Cy™ 3 dyes, resulting in an optimal match to filters designed for CyTM dyes.

Supplier: Anaspec Inc

HiLyte™ Fluor 750 acid, SE is the longest-wavelength amine-reactive HiLyte™ Fluor dye currently available. Its fluorescence emission maximum at 778 nm is well separated from commonly used far-red fluorophores such as HiLyte™ Fluor 647, HiLyte™ Fluor 680 or allophycocyanin (APC), facilitating multicolor analysis.

Supplier: Anaspec Inc

Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components

Supplier: Anaspec Inc

This is a reverse transcriptase (RT) epitope (Pol residues 476-484). Within HIV-1 RT the peptide appears to be the dominant HLA A*0201-restricted epitope. Was used to investigate possible mechanisms behind HIV-1 escape from CTL. IV9 is the actual epitope processed and presented in HIV-1-infected cell lines
Sequence:ILKEPVHGV
MW:991.2 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

This protease-activated receptor-1 (PAR-1) selective peptide induces cyclooxygenase-2 (COX-2) protein and mRNA expression in human endothelial cells. Studies show that intratracheal instillation of the PAR1-specific peptide increases lung edema during high-tidal-volume ventilation.
Sequence: TFLLRN
MW: 762.9 Da
% Peak Area by HPLC: ≥ 95%
Storage condition: -20°C

Supplier: Anaspec Inc

This Gastrin peptide is biotinylated at the N-terminus. It is similar to human Gastrin-17. However, native Gastrin-17 contains pyroglutamate at its N-terminus (Pyr), while this peptide contains Glutamate (E) at its N-terminus to allow for biotin coupling.
Sequence: Biotin-EGPWLEEEEEAYGWMDF-NH2
MW: 2342.6 Da
% Peak area by HPLC: 95
Storage condition: -20° C

Supplier: Anaspec Inc

Aß (1-40) together with Aß (1-42) are two major C-terminal variants of the Aß protein constituting the majority of Aßs. These undergo post-secretory aggregation and deposition in the Alzheimer’s disease brain. This peptide is biotinylated at its N-terminus.

Supplier: Anaspec Inc

This peptide corresponds to human keratin K18 amino acids 26-38, with an additional C-terminal cysteine. The sequence is identical to mouse K18 except that human K18 Val28 is replaced by alanine in the mouse sequence. Members of the 14-3-3 protein family bind the human intermediate filament protein keratin 18 (K18) in-vivo, in a cell-cycle- and phosphorylation-dependent manner. K18 Ser33 phosphorylation is essential for the association of K18 with 14-3-3 proteins and plays a role in keratin organization and distribution.
Sequence:RPVSSAApSVYAGAC
MW:1418.5 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

HNP-2 is a 29-residue peptide present in human neutrophils and is a member of the defensin family of antimicrobial peptides.
Sequence:CYCRIPACIAGERRYGTCIYQGRLWAFCC (Disulfide bridge: 1-29, 3-18, 8-28)
MW:3371 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

c-Myc, the product of the c-myc proto-oncogene, is a helix-loop-helix leucine zipper phosphoprotein that regulates gene transcription in cell proliferation, cell differentiation and apoptosis. This peptide is a human c-myc epitope.
Sequence:EQKLISEEDL
MW:1203.3 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

Rat/mouse Ghrelin differs from human Ghrelin on the 11th and 12th position - RV (Arg-Val) in rat/mouse and KA (Lys-Ala) in human. Ghrelin is an appetite stimulating peptide hormone secreted by stomach P/D1-type cells in humans and circulates in the bloodstream during fasting conditions.  Enzymatically n-octanoylated Serine3 of this 28-amino acid Ghrelin is the endogenous ligand specific for growth hormone secretagogue receptor 1a (GHSR1a). The GHSR1a receptor appears to be dedicated to Ghrelin and is widely expressed in different tissues. 
Sequence: GS-S(n-octanoyl)-FLSPEHQKAQQRKESKKPPAKLQPR
MW: 3314.8 Da
% Peak area by HPLC: 95
Storage condition: -20° C

Supplier: Anaspec Inc

TET 830 modified/T-helper epitope from tetanus toxoid is a universal human tetanus toxin T cell epitope. It induces T-cell activation and is used as a helper peptide in vaccinations.
Sequence:AQYIKANSKFIGITEL
MW:1797.2 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKgammaNEMO with the IKK complex is critical for the activation of the IKK complex and the subsequent activation of NF-kB.
Sequence:DRQIKIWFQNRRMKWKKTALDWSWLQTE
MW:3693.3 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

Compared to the 5-isomer, tetramethylrhodamine-6-maleimide is preferably used for thiol modifications of nucleotides and nucleic acids.

Supplier: Anaspec Inc

This is a hexapeptide with 6 histidines primarily used in tagging proteins. His tags have been used in affinity purification of recombinant proteins and have also been used in studying protein transduction in cells with the use of cell-penetrating proteins/peptides.
Sequence:HHHHHH
MW:841.9 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

Removal of any preexisting structures in lyophilized stocks of Aβ-peptide is the critical initial step for controlled aggregation studies. HFIP has been shown to break down β-sheet structure, disrupt hydrophobic forces in aggregated amyloid preparations, and promotes α-helical secondary structure. HFIP treatment of lyophilized Aβ-peptide resulted in a dense, homogeneous preparation of unaggregated peptide and samples can be stored as peptide films. HFIP treated Aβ-peptide samples can be stored as peptide films and can be used in controlled aggregation studies.
Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Molecular Weight: 4514.1
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

Supplier: Anaspec Inc

AM (22-52) is known as an adrenomedullin receptor antagonist and a cardiac depressant factor, although there is some discrepancy in the literature regarding the selectivity of ADM 22-52 as adrenomedullin receptor antagonist.
Sequence:TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2
MW:3576 Da
%Peak area by HPLC:≥95%
Storage condition: -20°C

Supplier: Anaspec Inc

Cathepsin G is the serine protease released by neutrophils upon their activation

Supplier: Anaspec Inc

This sequence is the hallmark of MUC1 mucin. MUC1 is a highly glycosylated type I transmembrane glycoprotein with a unique extracellular domain consisting of a variable number of tandem repeats (VNTR) of this 20 amino acid peptide It is overexpressed on the cell surface of many human adenocarcinomas and hematological malignancies, including multiple myeloma and B-cell lymphoma, making MUC1 broadly applicable target for immunotherapeutic strategies
Sequence:PDTRPAPGSTAPPAHGVTSA
MW:1887 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.
Sequence:EDIIRNIARHLAQVGDSMDR
MW:2309.6 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

This peptide is a naturally occurring mutant form of the wild type (WT) beta-Amyloid 1 to 42 peptide. The E22Q 'Dutch' mutant, also known as HCHWA-D, is caused by a point mutation in the beta-Amyloid encoding gene, with Glu replaced by Gln at position 22. Dutch E22Q mutation in beta-Amyloid causes familial cerebrovascular amyloidosis with abundant diffused amyloid plaque deposits. E22Q mutant and WT peptides are both stable in 'collapsed coil' conformations. The E22Q fibrils are more toxic for vascular cells than the WT fibrils.
Sequence: DAEFRHDSGYEVHHQKLVFFAQDVGSNKGAIIGLMVGGVVIA
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

Supplier: Anaspec Inc

This is a myristoylated PKCζ pseudosubstrate-derived ζ-inhibitory peptide (ZIP) found to inhibit an atypical type of Protein Kinase C ζ (zeta)
Sequence:Myr-RLYRKRIWRSAGR
MW:1928.5 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

This is amino acids 79 to 87 fragment of shepherdin, a novel peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability. For its potent and broad antitumor activity, selectivity of action in tumor cells versus normal tissues, and inhibition of tumor growth in vivo without toxicity, shepherdin may offer a promising approach for rational cancer therapy. This sequence is also known as K79–K90.
Sequence:KHSSGCAFL
MW:949.1 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

This peptide corresponds to residues 206–214 of murine islet-specific glucose-6-phosphatase catalytic subunit–related protein (IGRP). This peptide is T cells specific for proinsulin and IGRP induces diabetes in non-obese diabetic (NOD) mice.
Sequence: VYLKTNVFL
MW: 1096.3 Da
% Peak area by HPLC: 95
Storage condition: -20° C

Supplier: Anaspec Inc

Allophycocyanin (APC), highly fluorescent phycobiliprotein, is made up of alpha and beta subunits and is present as a trimer ( αβ)3, which is unstable and susceptible to dissociation at low concentrations. The monomer, αβ, has a lower fluorescence quantum yield compared to the trimer and the maximal absorption is also shifted to 620 nm. The chemically cross-linked APC trimer is much more stable than the native APC trimer, but still retains the same spectroscopic properties as the native APC trimer. APC labeled streptavidin, primary and secondary antibodies have been widely used in applications such as flow cytometry, live cell staining, and immunofluorescent staining.