Mouse Recombinant IL-1A (from E. coli)

Supplier: VWR International

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Supplier: VWR International

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About this item

Interleukin 1 alpha (IL-1α) is expressed by epithelial cells, activated macrophages, neutrophils, and endothelial cells to regulate immune responses. IL-1α signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic toll/IL-1 receptor (TIR) domain adapter. IL-1α and the independently regulated IL-1β protein have overlapping proinflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.

High quality

Low endotoxin

Affordable

Caution: For research use only.

Specifications

Conjugation:
Unconjugated
Protein Function:
Cytokine
Protein/peptide type:
Recombinant
Source:
E. coli
Species:
Mouse
Storage conditions:
–20 °C
Endotoxin content:
Endotoxin LAL (EU/µg) ≤0.1
Biological activity:
Bioactivity assay: D10.G4.1 proliferation; ED50 ≤0.01 ng/ml; Bioactivity ≥1.0×10⁸ units/mg
Gene ID:
P01582
Reconstitution instructions:
Sterile water at 0.1 mg/ml
Endotoxin-free:
N
Carrier-free:
Y
Protease-free:
N
Animal-free:
Y
Protein/peptide name:
IL-1A
Purity:
≥95%
Molecular weight:
18.1 kDa
Sequence:
MSAPYTYQSD LRYKLMKLVR QKFVMNDSLN QTIYQDVDKH YLSTTWLNDL QQEVKFDMYA YSSGGDDSKY PVTLKISDSQ LFVSAQGEDQ PVLLKELPET PKLITGSETD LIFFWKSINS KNYFTSAAYP ELFIATKEQS RVHLARGLPS MTDFQIS
Endotoxin level:
Low
Formulation:
10 mM sodium phosphate, pH 7.5
Nuclease-free:
N
Grade:
RUO
Shipping temperature:
RT
Tested applications:
Bioassay