You searched for: Antibodies

Supplier: Bioss

ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.

Supplier: Bioss

RNF35 belongs to the TRIM/RBCC family.

Supplier: Bioss

p130 is related both in structure and function to the retinoblastoma tumor suppressor protein and p107 (collectively known as pocket proteins) and is known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S phase of the cell cycle. Binding of p130 converts E2F transcription factors from transcriptional activators to transcriptional repressors.

Supplier: Bioss

Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.

Supplier: Bioss

Neuronal Marker Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease.

Supplier: Bioss

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.

Supplier: Bioss

Choline transporter. May be involved in membrane synthesis and myelin production.

Supplier: Antibodies.com

Rabbit monoclonal [ARC53046] antibody to Histone H3 (lactyl Lys18 for WB with samples derived from Human, Mouse and Rat.

Supplier: Antibodies.com

Recombinant rabbit monoclonal [C3e/4652R] antibody to CD3 epsilon for ELISA, WB and IHC-P with samples derived from Human.

Supplier: Bioss

Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.

Supplier: Bioss

Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation. Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through phosphylation of TYROBP, this interaction does not result in viral entry but stimulates proinflammatory cytokine release.

Supplier: Antibodies.com

Rabbit monoclonal [RM473] antibody to STAT6 for IHC and WB with samples derived from Human.

Supplier: Antibodies.com

Mouse monoclonal [TGB24] antibody to Thyroglobulin for ELISA and IHC-P with samples derived from Human.

Supplier: Antibodies.com

Mouse monoclonal [H5] antibody to CD307c for Flow Cytometry with samples derived from Human.

Supplier: Antibodies.com

Mouse monoclonal [4C8] antibody to CD52 for Flow Cytometry with samples derived from Human.

Supplier: Bioss

Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.

Supplier: Bioss

Leucine-rich repeats (LRRs) are 20-29 amino acid motifs that mediate protein-protein interactions. The primary function of these motifs is to provide a versatile structural framework for the formation of these protein-protein interactions. LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development. Several human diseases are associated with mutation in the genes encoding LRR-containing proteins. The leucine-rich repeat-containing protein 3B (LRRC3B), also designated LRP15, is a 259 amino acid protein that contains 3 LRR repeats. The gene encoding LRRC3B is a tumor suppressor gene that is regulated by DNA methylation. Decreased expression of LRRC3B has been shown in colorectal cancer and gastric cancer, making LRRC3B a candidate marker for those cancers.

Supplier: Bioss

The X and Y chromosomes are the human sex chromosomes. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. There are a number of conditions related to an unsual number and combination of sex chromosomes being inherited. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome. The CXorf56 gene product has been provisionally designated CXorf56 pending further characterization.

Supplier: Genetex

Rabbit polyclonal antibody to NCE2 (UBE2F) (ubiquitin-conjugating enzyme E2F (putative))

Supplier: Biotium

Cytokeratin 7 Monoclonal antibody, Clone: KRT7/1198, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Recom full-length human KRT7, Synonyms: CK-7, K2C7, Keratin 55K Type II, Application: IF, IHC, Size: 100uL

Supplier: Biotium

Cytokeratin 7 Monoclonal antibody, Clone: KRT7/1198, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: Recom full-length human KRT7, Synonyms: CK-7, K2C7, Keratin 55K Type II, Application: IF, IHC, Size: 100uL

Supplier: Biotium

Cytokeratin 7 Monoclonal antibody, Clone: KRT7/1198, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Recom full-length human KRT7, Synonyms: CK-7, K2C7, Keratin 55K Type II, Application: IF, IHC, Size: 100uL

Supplier: Biotium

TOX3, Monoclonal antibody, Clone: TOX3/1123, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: Recombinant fragment (139 Amino acid residues around aa 200-400) of human TOX3 protein, Synonyms: TOX3, Size: 100uL

Supplier: Biotium

TOX3, Monoclonal antibody, Clone: TOX3/1124, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Recombinant fragment (139 Amino acid residues around aa 200-400) of human TOX3 protein, Synonyms: TOX3, Size: 500uL

Supplier: Biotium

TOX3, Monoclonal antibody, Clone: TOX3/1124, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: Recombinant fragment (139 Amino acid residues around aa 200-400) of human TOX3 protein, Synonyms: TOX3, Size: 500uL

Supplier: Antibodies.com

Mouse monoclonal [PCRP-BCL11A-1H3] antibody to BCL11A for ELISA, IP, Flow Cytometry and IF with samples derived from Human.

Supplier: Antibodies.com

Rabbit monoclonal [ARC1629] antibody to Proteasome 20S LMP2 for WB and IHC with samples derived from Human, Mouse and Rat.

Supplier: Antibodies.com

Mouse monoclonal [PCRP-RBMS2-1B6] antibody to RBMS2 for ELISA, IP and Flow Cytometry with samples derived from Human.

Supplier: Antibodies.com

Mouse monoclonal [PCRP-HDAC3-2D4] antibody to HDAC3 for ELISA, IP, Flow Cytometry and IF with samples derived from Human.

Supplier: Bioss

Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.