Specifications

Antigen name:
CD127
Clonality:
Monoclonal
Clone:
A7R34
Conjugation:
PE (Phycoerythrin)
Host:
Rat
Isotype:
IgG2a kappa
Reactivity:
Mouse
Size:
100 µg
Gene ID:
16172
Cat. no.:
MSPP-100-1628

Specifications

About this item

Rat monoclonal antibody against mouse CD127, PE-conjugated.

B cells
Myeloid cells
T cells

This monoclonal antibody (clone A7R34) reacts with mouse cluster of differentiation 127 (CD127), a 60 to 90 kD type I transmembrane glycoprotein involved in the regulation of lymphopoiesis. CD127 is expressed on thymocytes, B cell precursors, T cells, and myeloid cells at the cell surface as a heterodimer with the common gamma chain (also known as CD132). This complex acts as a receptor for interleukin-7 (IL-7), which is an important cytokine in T and B cell development as well as in mature T cell homeostasis. Use this recombinant monoclonal antibody in applications requiring detection of CD127, such as flow cytometry (FC). Thymic stromal lymphopoietin (TSLP), a second cytokine, also binds to the receptor complex of CD127 and is involved in trigger activation of dendritic cells, allergy, and autoimmunity. CD127 has been reported to be a useful marker for identifying memory and effector T cells. The A7R34 antibody clone has been shown to block IL-7Rα signaling when administered in vivo.

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type: Anti-CD127 Rat Monoclonal Antibody [clone: A7R34] (PE)
Antigen: CD127
Clonality: Monoclonal
Clone: A7R34
Conjugation: PE
Epitope:
Host: Rat
Isotype: IgG2a kappa
Reactivity: Mouse