Anti-CD51 Mouse Monoclonal Antibody [clone: NKI-M9]

Catalog # MSPP-60043

Catalog # MSPP-60043

Supplier Number: 60043

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Specifications

Antigen name:
CD51
Clonality:
Monoclonal
Clone:
NKI-M9
Host:
Mouse
Isotype:
IgG2a kappa
Reactivity:
Human
Size:
100 µg
Gene ID:
3685
Cat. no.:
MSPP-60043

Specifications

About this item

Mouse monoclonal IgG2a antibody against human CD51 (integrin αV), unconjugated.

Mesenchymal stem
Progenitor cells

The NKI-M9 antibody reacts with CD51 (vitronectin receptor α chain, or integrin αV), a type I transmembrane glycoprotein containing two subunits (125 kDa and 24 kDa) which are generated by post-translational cleavage and are linked by a disulfide bond. CD51 associates non-covalently with integrin β1 (CD29), β3 (CD61), β5, β6, or β8 to form heterodimeric cell adhesion receptors for extracellular matrix components such as fibrinogen, collagen, fibronectin, laminin, osteopontin, thrombospondin, vitronectin, and von Willebrand factor. For example, association of CD51 and CD61 forms the integrin αv/β3 receptor primarily involved in binding vitronectin. In addition to mediating adhesion and cytoskeletal organization, CD51-containing integrins have roles in signal transduction and thereby modulate processes such as cell proliferation, differentiation, and migration. Both ligand binding and ligand-induced receptor clustering are necessary for initiating integrin-mediated responses. CD51 is expressed broadly on many types of cells, including endothelial cells, fibroblasts, monocytes, macrophages, platelets (at relatively low levels), and osteoclasts. It is also found on hepatoma, melanoma, and neuroblastoma cells.

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type: Anti-CD51 Mouse Monoclonal Antibody [clone: NKI-M9]
Antigen: CD51
Clonality: Monoclonal
Clone: NKI-M9
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Human