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Specifications
- Antibody type:Primary
- Antigen name:BRCA1 (Ser1466)
- Clonality:Polyclonal
- Gene ID:672
- Host:Rabbit
- Isotype:IgG (H, L)
- Reactivity:Human
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Size:100 µl
- Storage buffer:0.01 M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% glycerol
- Molecular weight:208 kDa
- Storage temperature:Store at −20 °C for 12 months
- Concentration:1 µg/µl
- Purification:Purified by protein A
- Packaging:Vial
Specifications
About this item
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
Type: Primary
Antigen: BRCA1 (Ser1466)
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG (H, L)
Reactivity: Human