SARS-CoV-2 Recombinant SARS-CoV-2 Spike Protein in SMALP 140 (from HEK293 cells)

Catalog #: 77392-862

Supplier: CUBE BIOTECH

New Product

CAS Number:

SARS-CoV-2 Recombinant SARS-CoV-2 Spike Protein in SMALP 140 (from HEK293 cells)

Catalog #: 77392-862

Supplier: CUBE BIOTECH

New Product

CAS Number:

Specifications

Protein/peptide type:
Recombinant
Source:
HEK293 cells
Species:
SARS-CoV-2
Size:
25 µg
Storage conditions:
−80 °C, avoid freeze-thaw cycles
Amino acid number:
1286
Protein synonyms:
Spike glycoprotein
Protein/peptide name:
SARS-CoV-2 Spike Protein in SMALP 140
Purity:
>98%, determined via SDS-PAGE
Molecular weight:
142114 Da
Shipping temperature:
Dry ice
Cat. no.:
77392-862

Specifications

About this item

The coronavirus, also known as SARS-CoV-2, enters the cell by using its surface SPIKE. SPIKE is processed on the cell's surface by TMPRSS2, a serine protease. It then subsequently binds to ACE2 a cell surface receptor.

Alternative names: SPIKE_SARS2 Spike glycoprotein
UniProt Number: P0DTC2
Protein class: Single span transmembrane proteiN
Organism: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Sequence, explained: Full-length sequence (aa 1 – 1273), furin cleavage site 'RRAR' mutated to 'GSAG'; C-terminal Rho1D4 tag fused with spacer 'GSSG' to protein sequence
Affinity tags: C-terminal Rho1D4-tag
Buffer composition: 20 mM Hepes pH 7.5; 150 mM NaCl, buffer does not contain free SMALP 140
Stabilization agent: SMALP 140
Purified via: PureCube Rho1D4 Agarose
Function: Host cell surface receptor binding; fusion of virus membrane with host endosome membrane

The Native SPIKE protein is a trimer that is located in the coronavirus membrane. Therefore to get pure & native SPIKE this trimer needs to be kept intact. And Cube Biotech offers stabilized intact form of SPIKE.

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