Human Cardiac-Related Fibroblasts include Aortic Adventitial Fibroblasts (AoAF) isolated from the tunica external of the ascending or descending aorta and cardiac fibroblasts (NHCF-A and -V) isolated from the atrium or ventricle. Cells are isolated from normal, adult heart tissue. Cryopreserved cells are shipped at passage 2.

Clonetics® NHCF-V & -A are guaranteed through 5 population doublings and express ≥90% collagen I and ≤10% Von Willibrand factor VIII after thaw. Clonetics® AoAF are guaranteed through 10 population doublings and are negative for alpha smooth muscle actin. All cells test negative for mycoplasma, bacteria, yeast and fungi. HIV-1, hepatitis B and hepatitis C are not detected for all donors and/or cell lots.

Applications: Vascular diseases, Neointimal formation, Vascular remodeling, Atherosclerosis, Hypertension, Myocardial repair, Extracellular maintenance during cardiac cell / tissue growth, Cardiac Fibrosis Paracrine signalling, Toxicology, Gene expression.