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Specifications
- Antigen name:Avelumab
- Clonality:Monoclonal
- Clone:12H7
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Mouse
- Isotype:IgG1 kappa
- Size:40 μg
- Cross adsorption:No
- Form:Lyophilized
- Storage buffer:This product is lyophilized with PBS, pH 7.2, containing 0.02% sodium azide
- Storage temperature:The lyophilized product remains stable up to 1 year at −20 °C from date of receipt. Upon reconstitution, it can be stored for 2 - 3 weeks at 2...8 °C or for up to 12 months at −20 °C or below. Avoid repeated freezing and thawing cycles
- Concentration:Reconstitute the lyophilized powder with deionized water (or equivalent) to a final concentration of 0.5 mg/ml.
- Immunogen:Avelumab
- Cat. no.:77007-586
- Packaging:Vial
Specifications
About this item
Avelumab with trade name Bavencio, is an FDA-approved drug to treat Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma. Avelumab is a whole monoclonal antibody of isotype IgG1 that binds to the programmed death-ligand 1 (PD-L1) and therefore inhibits binding to its receptor programmed cell death 1 (PD-1). PD-L1 can be highly expressed on certain tumors, which is thought to lead to reduced activation of immune cells (cytotoxic T-cells in particular) that might otherwise recognize and attack the cancer. Inhibition of PD-L1 by Avelumab can remove this inhibitor effect and thereby engender an anti-tumor response. It is one of several ways to block inhibitory signals related to T-cell activation, a more general strategy known as immune checkpoint inhibition. Anti-Avelumab Antibody (12H7), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Avelumab.
- High specificity
- High affinity
- High stability
GenScript has developed a broad range of off-the-shelf anti-idiotype antibodies against blockbuster drugs to help accelerate your research of biosimilars.
Type:
Antigen: Avelumab
Clonality: Monoclonal
Clone: 12H7
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: