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Specifications
- Antibody type:Primary
- Antigen name:UVRAG
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Size:100 µl
- Environmentally Preferable:
- Epitope:501-600/699
- Form:Liquid
- Gene ID:7405
- Antigen synonyms:UV radiation resistance associated gene protein|p63|UV radiation resistance associated|Disrupted in heterotaxy|UVRAG|UV radiation resistance associated gene|DHTX|UVRAG_HUMAN|UV radiation resistance-associated gene protein
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0.01 M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human UVRAG/DHTX
- Purification:Purified by Protein A
- Cat. no.:76121-060
- Packaging:Vial
Specifications
About this item
UVRAG, also known as p63 or DHTX, is a 699 amino acid cytoplasmic protein. UVRAG has been shown to activate the BECN1/PI 3-kinase complex, which promotes autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Mutations in the gene encoding UVRAG have been associated with colon cancer, suggesting that UVRAG is also involved in suppressing the proliferation and tumorigenicity of human colon cancer cells. UVRAG has been found to complement the ultraviolet sensitivity of xeroderma pigmentosum group C cells. Ubiquitously expressed, UVRAG is found at highest levels in kidney, lung, liver and brain. UVRAG contains one C2 domain, which is thought to be involved in calcium-dependent phospholipid binding.
Type: Primary
Antigen: UVRAG
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 501-600/699
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat