Fully porous polystyrene/divinylbenzene media suitable for oligonucleotide and protein purification.

• Discovery stage to multi-kg cGMP production reduces method development time
• Chemical stability for separations, optimization, sanitation, and regeneration increases selectivity and column lifetime
• Single batch packing of multiple columns reduces system downtime and validation costs

The PLRP-S media, rigid poly(styrene/divinylbenzene) particles, are available in a range of pore sizes for small molecule, synthetic biomolecule and macromolecule purification. Their thermal and chemical stability makes them ideal for purifications that require extreme conditions for sample preparation, compound elution, and column regeneration. With a wide choice of pore sizes and extended range of operating conditions, PLRP-S provides more options to achieve the optimum process. Particle sizes range from 3 to 50 μm for scale-up from the μg/mg discovery stage to multi-kg cGMP production. Excellent chemical stability, up to 1 M NaOH, permits sanitation and regeneration that increase column lifetime. PLRP-S media batch sizes of up to 600 L are available, providing single batch packing of multiple columns.