Fully porous quaternary amine strong anion exchange suitable for oligonucleotide and protein purification.

• Anion-exchange purifications over a wider pH range extend applications
• HPLC flow rates and rapid equilibration reduce purification cycle times
• Large pore size for improved mass transfer delivers high speed, high resolution purifications
• 1000 Å pore size for high capacity purifications
• 4000 Å gigaporous particles with improved mass transfer for large biomolecules and high-speed, high-resolution purifications

PL-SAX strong anion-exchange materials are extremely hydrophilic and are designed for purification of biomolecules. The materials are totally polymeric and are chemically and thermally stable over a full range of HPLC conditions. The strong anion-exchange functionalities, covalently linked to a chemically stable polymer, facilitate anion-exchange purifications over a wider pH range. This stability can be exploited for column sanitation and clean-up, and also enables the use of denaturing conditions and stabilizing/solubilizing agents, as encountered in the purification of synthetic oligonucleotides with self-complementary sequences.