High density non-porous weak cation exchanger for mAb charge variant analysis.

• A packing support composed of a rigid, spherical, highly cross-linked polystyrene divinylbenzene (PS/DVB) non-porous bead
• Particles grafted with a hydrophilic, polymeric layer, virtually eliminating non-specific binding of antibody proteins
• A different process is used to layer the weak cation-exchange phase to the particle making it a higher density than the Agilent Bio WCX column particles
• Specifically designed for the separation of charge isoforms of monoclonal antibodies

Thorough characterization of monoclonal antibodies includes the identification and monitoring of acidic and basic isoforms. The Agilent Bio MAb HPLC columns feature a unique resin specifically designed for high-resolution charge-based separations of monoclonal antibodies. Bio MAb columns are available in 1.7 μm, 3 μm, 5 μm, and 10 μm sizes, providing higher resolution with the smaller particles. The Bio MAb column features a highly uniform, densely packed, weak cation exchange layer. This layer of the Bio MAb column is chemically bonded to the hydrophilic, polymeric coating of the Bio MAb column. View our full range of bioHPLC columns for your area of interest, get resources, and take advantage of special offers.