Anti-Herpes Simplex Virus Type I Antibody was tested in IHC-P with positive control infected tissues. Consult references (Kiernan, 1981: Sheehan & Hrapchak, 1980) for further details on specimen preparation. The user is advised to validate the use of the products with their tissue specimens prepared and handled in accordance with their laboratory practices.

• Reacts with the HSV type 1 specific antigen
• Tested in IHC-P with positive control infected tissues

The herpes simplex (HSV) (also known as cold sore, night fever or fever blister) is a virus that causes a contagious disease. There are two main types of Herpes Simplex Virus (HSV) , 1 and 2; and they belong to a family that includes Epstein-Barr virus (EBV) and Varicella zoster (chicken pox) virus. HSV1 and HSV2 are extremely difficult to distinguish from each other. The HSV-1 strain generally appears in the orafacial organs. HSV2 usually resides in the sacral ganglion at the base of the spine. These viruses have a large DNA genome, capsid, and a lipid bilayer membrane derived from the nuclear membrane of the last host. These viruses are capable of entering a latent phase where the host shows no visible sign of infection. Envelope glycoprotein C (gC) and glycoprotein B (gB) bind to cell surface partials heparin sulfate. Receptor binding protein glycoprotein D (gD) binds to HVEM, nectin-1, and 3-O sulfated heparin sulfate forming complexes with glycoprotein H (gH) and glycoprotein (gL) creating an entry pore for the viral capsid.