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- Enzyme type:Recombinant
- Enzyme name:OGG
- Enzyme synonyms:Oxoguanine Glycosylase
- Concentration:8,000 units/ml
- Cat. no.:CA76640-796
Bifunctional DNA glycosylase with DNA N-glycosylase and AP lyase activities
- Thermostable
- Isolated from a recombinant source
- Supplied with 10X Reaction Buffer
Thermostable OGG is an archaeal 8-oxoguanine (8oxoG) DNA glycosylase which acts both as a N-glycosylase and an AP-lyase. The N-glycosylase activity releases the damaged purine (8-oxoguanine) from double stranded DNA, generating an apurinic (AP) site. The AP-lyase activity cleaves 3' to the AP site leaving a 5' phosphate and a 3'-phospho-alpha, beta-unsaturated aldehyde. Unlike some other DNA glycosylases, Thermostable OGG specifically recognizes and cleaves only 8oxoG and no other modified bases.