Mouse Recombinant IL-36RA (from E. coli)

About this item

The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36alpha (IL-1F6), IL-36beta (IL-1F8), and IL-36gamma (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-kappaB signaling induced by either IL-36alpha, beta or gamma by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant Murine IL-36RA is an E. coli-derived 16.9 kDa protein containing 154 amino acid residues.

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Specifications

Conjugation:
Unconjugated
Protein/peptide type:
Recombinant
Source:
E. coli
Species:
Mouse
Biological activity:
Measured by its ability to inhibit secretion of IL-8 by A431 cells in the presence of human IL-36gamma.
Gene ID:
54450
Animal-free:
Y
Protein synonyms:
IL-1 delta|Interleukin-36RA|FIL1 delta|IL-1RP3|IL-1L1|IL-1HY1|IL-1F5|IL-1ra Homolog 1
Protein/peptide name:
IL-36RA
Purity:
98%
Molecular weight:
16.9 kDa
Sequence:
VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD
Endotoxin level:
Low
Formulation:
Lyophilized
Shipping temperature:
Ambient