Human Recombinant PDGF-AA (from E. coli)
Product Details & Documents
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet alpha-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids).
- Animal-free
Specifications
Specifications
- Size:1 mg
- Protein/peptide name:PDGF-AA
- Protein synonyms:Osteosarcoma-derived Growth Factor (ODGF)|Glioma-derived growth factor (GDGF)|Platelet-Derived Growth Factor-AA
- Purity:98%
- Endotoxin level:Low
- Sequence:SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPT
- Source:E. coli
- Biological activity:The ED50 as determined by the dose-dependent stimulation of thymidine uptake by Balb/c 3T3 cells is ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg.
- Molecular weight:28.5 kDa
- Shipping temperature:Ambient
- Cat. No.:76081-524
- Protein/peptide type:Recombinant
- Gene ID:5154
- Formulation:Lyophilized
- Conjugation:Unconjugated
- Species:Human
- Animal-free:Y
Specifications
#: CA21905-026
Supplier: Kimberly-Clark