You searched for: Antibodies

Supplier: Rockland Immunochemical

800 Conjugated Antibody The Emission Spectra For This Dylight Conjugate Match The Principle Output Wavelengths Of Most Common Fluorescence Instrumentation. Rabbit Host

Supplier: Rockland Immunochemical

Anti-PKM2 Antibody was designed, produced, and validated as part of the Joy Cappel Young Investigator Award (JCYIA). Pyruvate kinase has been shown to be expressed in tumor, embryonic and normal proliferating cells in varying levels. Studies show that when PKM2 is secreted it can induce EGFR phosphorylation which stimulates the EGFR downstream pathway. Previously PKM has been shown to be critical for aerobic glycolysis. Four isoforms of PKM play alternative roles within the system and post-translational modifications along these isoforms induce multiple pathways making this Anti-PKM2 antibody ideal for investigators involved in cancer research and post-translational modifications.

Supplier: Rockland Immunochemical

Anti-MDC1 Antibody is suitable for use in WB and Immunofluorescence microscopy. Expect a band approximately ~184kDa corresponding to specific lysates. Specific conditions for reactivity should be optimized by the end user.

Supplier: Immunoreagents

ImmunoReagents’ Biotinylated antibody conjugates are widely used due to their ability to enhance antibody signal in most immunoassays. Biotinylated secondary antibodies are used in most immunoassay formats (i.e., ELISA, Immunohistochemistry (IHC), and Western blotting). While Biotinylated antibodies by themselves do not produce a signal that can be visualized, biotin has a high affinity and specificity to Streptavidin/Avidin. Using ImmunoReagents’ streptavidin conjugates with biotinylated antibodies results in signal amplification.

Supplier: Immunoreagents

ImmunoReagents’ Biotinylated antibody conjugates are widely used due to their ability to enhance antibody signal in most immunoassays. Biotinylated secondary antibodies are used in most immunoassay formats (i.e., ELISA, Immunohistochemistry (IHC), and Western blotting). While Biotinylated antibodies by themselves do not produce a signal that can be visualized, biotin has a high affinity and specificity to Streptavidin/Avidin. Using ImmunoReagents’ streptavidin conjugates with biotinylated antibodies results in signal amplification.

Supplier: Immunoreagents

ImmunoReagents’ Biotinylated antibody conjugates are widely used due to their ability to enhance antibody signal in most immunoassays. Biotinylated secondary antibodies are used in most immunoassay formats (i.e., ELISA, Immunohistochemistry (IHC), and Western blotting). While Biotinylated antibodies by themselves do not produce a signal that can be visualized, biotin has a high affinity and specificity to Streptavidin/Avidin. Using ImmunoReagents’ streptavidin conjugates with biotinylated antibodies results in signal amplification.

Supplier: Rockland Immunochemical

This purified antibody has been tested for use in ELISA and western blotting. By western blot a band approximately 30.3 kDa in size corresponding to human IL17-A Protein is expected in the appropriate cell lysate or extract.

Supplier: Rockland Immunochemical

Supplier: Rockland Immunochemical

Igg F(C) (Donkey) Suitable For Immunomicroscopy And Flow Cytometry Or Facs Analysis As Well As Other Antibody Based Fluorescent Assays Requiring Lot-To-Lot Consistency

Supplier: Rockland Immunochemical

MEK2 antibodies detect the MEK2 isoform.  Mitogen-activated protein kinase kinase 2, also known as MEK2 or MKK2, is an integral component of the MAP kinase cascade that regulates cell growth and differentiation.   This pathway also plays a key role in synaptic plasticity in the brain.  Activated MEK 2 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase.   MEK1 and MEK2 are about 80% identical to each other, and nearly identical within the kinase domain.  This antibody does not react with MEK1.  The MEK2 antibody is ideal for investigators involved in Neuroscience, Cell Signaling and Cancer Research.

Supplier: Tonbo Biosciences

The 145-2C11 antibody is specific for mouse CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells. The 145-2C11 antibody is a widely used phenotypic marker for mouse T cells. In addition, binding of 145-2C11 antibody to CD3e can induce cell activation. A recent publication of the crystal structure of a murine CD3e-mitogenic antibody complex provides further insight into the action of commonly used agonist antibodies (Fernandes, R.A. et al. 2012. J. Biol. Chem. 287: 13324-13335).

Supplier: Tonbo Biosciences

The 53-7.3 monoclonal antibody is specific for mouse CD5, a 67 kDa protein that is expressed on most thymocytes, mature T cells and the B-1 subset of B cells. CD5 is a member of the scavenger receptor cysteine-rich protein superfamily and is a ligand for the c-type lectin CD72. CD5 is also known as Leu-1 and functions to modulate antigen receptor signaling on T and B cells.

Supplier: Immunoreagents

This conjugate is suitable for immunomicroscopy and flow cytometry. The optimal working dilution should be determined by the investigator. Suggested starting dilution(?): · 1:20 - 1:2,000 for most applications

Supplier: Rockland Immunochemical

Anti Golden Syrian & Armenian Hamster IgG (H&L) antibody is suitable for Elisa, Western Blot and immunochemistry. Specific conditions for reactivity should be optimized by the end user.

Supplier: Rockland Immunochemical

This purified antibody has been tested for use in neutralizations, ELISA and western blotting. Reactivity is also expected in radioimmunoassay.

Supplier: Rockland Immunochemical

This monoclonal antibody contains TBS/1% BSA and is suitable for ELISA, immunochemistry and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 116 kDa in size corresponding to PgR.

Supplier: Tonbo Biosciences

Goat anti-Human IgG Fc - Affinity Pure, HRP Conjugate

Supplier: Rockland Immunochemical

IL-27 is expressed in activated antigen presenting cells including monocytes, endothelial cells, and dendritic cells, for example mouse CD4 splenocytes. This purified antibody has been tested for use in western blotting.

Supplier: Tonbo Biosciences

Rabbit anti-Human IgM (mu chain) - Affinity Pure, FITC Conjugate

Supplier: Tonbo Biosciences

Goat anti-Human IgA (alpha chain) - Affinity Pure, FITC Conjugate

Supplier: Rockland Immunochemical

(H&L) (Goat) (Min X Mouse And Rat Serum Proteins) Secondary Antibodies Are Ideal For Western Blotting, Immunohistochemistry, Fluorescent Microscopy, Elisa As Well As Other Protein Detection Assays.

Supplier: Rockland Immunochemical

Anti-Kv1.1 Extracellular Antibody is suitable for use in WB and Immunofluorescence microscopy. Expect a band approximately ~56kDa (could be 65-85 depending on glycosylation) on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Supplier: Rockland Immunochemical

MEK1 antibodies detect the MEK1 isoform. Mitogen-activated protein kinase kinase 1, also known as MKK or MEK, is an integral component of the MAP kinase cascade that regulates cell growth and differentiation. This pathway also plays a key role in synaptic plasticity in the brain. Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase. The MEK1 antibody is ideal for investigators involved in Neuroscience, Cell Signaling and Cancer Research.

Supplier: Rockland Immunochemical

MEK1 antibodies detect the MEK1 isoform. Mitogen-activated protein kinase kinase 1, also known as MKK or MEK, is an integral component of the MAP kinase cascade that regulates cell growth and differentiation. This pathway also plays a key role in synaptic plasticity in the brain. Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase. The MEK1 antibody is ideal for investigators involved in Neuroscience, Cell Signaling and Cancer Research.

Supplier: Rockland Immunochemical

Anti-Monkey IgG (H&L) HRP antibody generated in rabbit detects specifically monkey IgG heavy and light chains. Secreted as part of the adaptive immune response by plasma B cells, immunoglobulin G constitutes 75% of serum immunoglobulins. IgG binds to viruses, bacteria, as well as fungi and facilitates their destruction or neutralization via agglutination (and thereby immobilizing them), activation of the compliment cascade, and opsinization for phagocytosis. The whole IgG molecule possesses both the F(c) region, recognized by high-affinity Fc receptor proteins, as well as the F(ab) region possessing the epitope-recognition site. Both heavy and light chains of the antibody molecule are present. This peroxidase conjugated anti-Monkey IgG (H&L) secondary antibody is ideal for investigators who routinely perform western-blot, immunoprecipitation and more general immunoassays. When choosing a secondary antibody product, consideration must be given to species and immunoglobulin specificity, conjugate type, fragment and chain specificity, level of cross-reactivity, and host-species source and fragment.

Supplier: Rockland Immunochemical

HbA antibodies detect the hemoglobin beta subunit wild type variant A isoform. Functional adult hemoglobin (Hb) is a hetero tetramer composed of 2 alpha and 2 beta subunits (α2β2). Common isoform variants of hemoglobin include HbA, HbS, HbC, HbF, and HbA-2. Sickle cell disease (SCD), thalassemias and hemoglobinopathies occur when aberrant forms of hemoglobin are expressed in children and adults. Globin gene mutations affect the structure and expression levels of Hb. Sickle cell disease and the more benign sickle cell trait are observed in more than 100 million people globally. Perhaps the most significant mutation is the E6V in the beta subunit and the cause of SCD, but other relevant isoforms of Hb are observed. HbA antibody cross reacts with HbA-2 but does not react other forms Hb. This antibody is ideal for investigators involved in Cardiovascular and developmental biology research.

Supplier: Tonbo Biosciences

The HI30 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, CD45RO and others.

Supplier: Tonbo Biosciences

Goat anti-Human IgA (alpha chain), F(ab)'2 Fragment - Affinity Pure, Biotin Conjugate

Supplier: Tonbo Biosciences

Goat anti-Mouse IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/bovine, goat, human, rabbit or rat IgG

Supplier: Rockland Immunochemical

This monoclonal antibody is suitable for immunofluorescence microscopy, FLISA and western blotting. Expect a band approximately 56 kDa in size corresponding to phosphorylated AKT Protein by western blotting in the appropriate cell lysate or extract.