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Specifications
- Antibody type:Primary
- Clonality:Monoclonal
- Clone:15C2.C11.F2.G11
- Host:Mouse
- Isotype:IgG1 kappa
- Antigen symbol:HbBc
- ELISA:Yes
- Size:25 µL
- Western blot:Yes
- Shipping temperature:Dry Ice
- Purification:Protein A purified
- Cat. no.:76234-992
Specifications
About this item
HbC antibodies detect the E6K mutant in the hemoglobin beta subunit. Functional hemoglobin (Hb) is a hetero tetramer composed of 2 alpha and 2 beta subunits (α2β2). Common isoform variants of hemoglobin include HbA, HbS, HbC, HbF, and HbA2. Sickle cell disease (SCD), thalassemias and hemoglobinopathies occur when aberrant forms of hemoglobin are expressed in children and adults. Globin gene mutations affect the structure and expression levels of Hb. Sickle cell disease and the more benign sickle cell trait are observed in more than 100 million people globally. Less significant than the SCD-E6V, HbC E6K mutation causes a mild hemolytic anemia. HbC antibody does not react to other forms of Hb. This antibody is ideal for investigators involved in Cardiovascular and developmental biology research.
Anti-Hemoglobin beta C (MOUSE) antibody is suitable for use in Western Blotting. Specific conditions of reactivity should be optimized by the end user. Expect a band of approximately 16 kDa.
Type: Primary
Antigen: HbBc
Clonality: Monoclonal
Clone: 15C2.C11.F2.G11
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: