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Specifications
- Antibody type:Primary
- Clonality:Polyclonal
- Host:Rabbit
- Antigen symbol:AKT1
- ELISA:Yes
- Flow cytometry:Yes
- Size:25 µL
- Western blot:Yes
- Modification:Phosphorylation
- Shipping temperature:Dry Ice
- Purification:immunoaffinity chromatography
- Cat. no.:76262-930
Specifications
About this item
AKT is a component of the PI-3 kinase pathway and is activated by phosphorylation at Ser 473 and Thr 308. AKT is a cytoplasmic protein also known as Protein Kinase B (PKB) and rac (related to A and C kinases). AKT is a key regulator of many signal transduction pathways. AKT Exhibits tight control over cell proliferation and cell viability. Overexpression or inappropriate activation of AKT is noted in many types of cancer. AKT mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. AKT has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation.
AKT antibody is phospho specific for pT308 and is suitable for western blotting, Flow Cytometry, and ELISA.
Type: Primary
Antigen: AKT1
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: