Human Recombinant IL-37 (from E. coli)

About this item

Animal-free

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-37 (IL-1F7), which acts as a modulator of the immune response. Reduction of IL-37 synthesis in PBMCs leads to increased production of pro-inflammatory cytokines including IL-1 alpha, IL-1 beta, IL-6 and TNF- alpha. The role of IL-37 as an inhibitor of the innate inflammatory response is also corroborated by the observation that it is highly expressed in synovial tissue from patients with rheumatoid arthritis. Full length IL-37 resides primarily in the cytoplasm, but after activation through cleavage by CASP1, it can translocate to the nucleus where it exerts its activity by direct interaction with SMAD3. Recombinant Human IL-37 is a 19.4 kDa protein consisting of 174 amino acids, corresponding to the mature activated form of IL-37.

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Specifications

Conjugation:
Unconjugated
Protein/peptide type:
Recombinant
Source:
E. coli
Species:
Human
Storage conditions:
Store at –20 °C prior to reconstitution.
Endotoxin content:
>0.1 ng/μg
Biological activity:
Biological Activity tests can vary. Please refer to the Product CoA for information.
Form:
Lyophilized
Gene ID:
27178 Q9NZH6
Reconstitution instructions:
Reconstitution instructions can vary. Please refer to the product CoA for info.
Protease-free:
Y
Animal-free:
Y
Protein synonyms:
IL-1H4|IL-1F7|Interleukin-37|IL-1ζ (zeta)
Protein/peptide name:
IL-37
Purity:
0.95
Molecular weight:
19.4 kDa
Sequence:
MVHTSPKVKN LNPKKFSIHD QDHKVLVLDS GNLIAVPDKN YIRPEIFFAL ASSLSSASAE KGSPILLGVS KGEFCLYCDK DKGQSHPSLQ LKKEKLMKLA AQKESARRPF IFYRAQVGSW NMLESAAHPG WFICTSCNCN EPVGVTDKFE NRKHIEFSFQ PVCKAEMSPS EVSD
Endotoxin level:
Low
Formulation:
Formulation can vary. Please refer to product CoA for information.
Shipping temperature:
Ambient