Intact PTH ELISA measuresintact Parathyroid Hormone (PTH) concentration in human serum and plasma.

• Dynamic Range: 7 - 210 pg/ml
• Sensitivity: 0.49 pg/mL 
• Incubation: 3.5 hours

Parathyroid Hormone (PTH) is a hormone synthesized in the parathyroid gland in a 115 aminoacids form that, after post-translational modifications, reaches the biologically active form of 84 amino acids (Intact PTH).
PTH is released in the blood, where is rapidly degraded (half-life about 4 minutes); intact PTH concentration in the blood is regulated by a negative feedback mechanism that involves calcium in serum. PTH is degraded inside the parathyroid glands, in liver, kidneys and bones. A high concentration of intact PTH in the blood may indicate kidney dysfunction.
The measurement of the concentration of intact PTH in the blood is an effective way to diagnose the primary hyperparathyroidism and distinguish it from other diseases not related to parathyroid: in fact, intact PTH is elevated in 90% of cases of hyperparathyroidism.