The 61D3 monoclonal antibody specifically reacts with CD14, a cell surface anchored glycoprotein that is primarily expressed on monocytes, inerfollicular macrophages, and a subset of dendritic cells. CD14 associates with MD-2 (LY-96) and TLR4 to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The CD14/MD-2/TLR4 receptor complex signals via MyD88, TIRAP, and TRAF6, and ultimately activates NF-kappaB.

Type: Primary
Antigen: CD14
Clonality: Monoclonal
Clone: 61D3
Conjugation: PE (Phycoerythrin)
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human