Order Entry
Canada
ContactUsLinkComponent
Human Recombinant Renin (from HEK293 Cells)
Human Recombinant Renin (from HEK293 Cells)
  103010-344
 :  
Human Recombinant Renin (from HEK293 Cells)
  103010-344
 :  AS-72041
 :  

Some Products May Appear Restricted

To ensure a smooth and speedy checkout, please log in to your account. Some items may show as restricted simply because you're not logged in.

If you do not have an account, you can register using our registration webform (https://www.avantorsciences.com/ca/en/login/register)

 

If you're still seeing restrictions after logging in, certain products—like chemicals or medical devices—require additional account verification steps to be able to place an order. Some items may additionally require a specific license or customer documentation;  additional documentation will be requested for these items prior to shipment. 

 

  • Conjugation:
    Unconjugated
  • Protein/peptide type:
    Recombinant
  • Source:
    HEK293 cells
  • Species:
    Human
  • Size:
    5 µg
  • Storage conditions:
    –78 °C
  • UniProtKB:
    P00797
  • Protein/peptide name:
    Renin
  • Purity:
    >99% as estimated by SDS-PAGE
  • Molecular weight:
    40 kDa
  • Cat. no.:
    103010-344
  • Supplier No.:
    AS-72041

 

 

Renin, a highly specific aspartyl protease, cleaves angiotensinogen, produced in the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE (Angiotensin Converting Enzyme). Angiotensin II constricts blood vessels, leading to increased blood pressure. It also increases the secretion of ADH and aldosterone, and stimulates the hypothalamus to activate the thirst reflex. Since an overactive renin-angiotensin system leads to hypertension, renin is proposed as a therapeutic target for this disease

The recombinant human pro-renin was expressed in HEK cells and converted to the active renin. After affinity chromatography, the active enzyme has a purity of >99% by SDS-PAGE. The molecular mass of active human renin is approximately 40 kDa.
The activity of enzyme can be measured in FRET-based assays