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- Conjugation:DNP(2,4-Dinitrophenol)
- Size:0.1 mg
- Storage conditions:–20 °C
- Protein synonyms:Cathepsin K|Cathepsin FRET Peptide
- Protein/peptide name:Cathepsin K Substrate
- Purity:95%
- Molecular weight:920 Da
- Sequence:Abz-HPGGPQ-EDDnp
- Cat. no.:103007-314
- Supplier No.:AS-62368
Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.
This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2,4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.
Sequence:Abz-HPGGPQ-EDDnp
MW:920 Da
% peak area by HPLC:95
Storage condition:-20° C