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Specifications
- Conjugation:Unconjugated
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Size:100 µg
- Tag sequence:GST Tag
- Storage conditions:Store at 2-4 °C for immediate use within 1-2 weeks or at –80 °C for up to 12 months
- Gene ID:AAC04279.1
- Protein synonyms:Tau 441 labeled|Tau GST|Human Tau 441 GST|Tau-441 GST labeled
- Protein/peptide name:Tau
- Purity:> 90% as determined by SDS-PAGE
- Molecular weight:71.8 kDa
- Cat. no.:103001-724
- Supplier No.:AS-55557-100
Specifications
About this item
The sequence (Accession # AAC04279.1) corresponding to the full length human Tau-441 (2N4R isoform) protein along with GST tag at N-terminal was expressed in E. coli. The recombinant GST-Tau-441 protein was purified from bacterial lysate using proprietary method.
Microtubule associated protein (Tau) is found predominantly in the central neural system and its major function is to promote assembly and to stabilize neuronal microtubules. Six isoforms of Tau were identified in humans that are differentiated by the exclusion or inclusion of exons 2, 3, and 10. Tau-441 is the longest of Tau isoforms, consisting of 441 amino acids with molecular mass of 45.8 kDa. Under physiological conditions Tau can undergo abnormal phosphorylation, truncation, or other modifications that result in the protein detachment from microtubules. These modified Tau molecules can self-associate and form different types of aggregates including neurofibrillary tangles (NFTs) found in brains of patients with neurodegenerative diseases such as Alzheimer’s disease.