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Specifications
- Conjugation:HiLyte Fluor® 488
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Size:200 µg
- Storage conditions:Store at 2-4 °C for immediate use within 1 week or at –80 °C for up to 12 months. Keep in dark and avoid repeated freeze-thaw cycles.
- Gene ID:NP_000336
- Protein synonyms:Synuclein-HiLyte™ Fluor 488|α-Synuclein (1-140) labeled|Synuclein 1-140 HF 488|Synuclein-HF 488
- Protein/peptide name:alpha-Synuclein
- Purity:> 95% as determined by SDS-PAGE
- Cat. no.:103004-984
- Supplier No.:AS-55457
Specifications
About this item
The recombinant human a-synuclein (1-140) (GenBank Accession # NP_000336) was expressed and purified from E. coli and conjugated with the fluorescence dye HiLyte FluorTM 488. This protein is produced without affinity tag.
α-Synuclein is a major component of Lewy bodies in the affected neurons in Parkinson's disease. This protein has a mass of 14.5 kDa (140 amino acids long) and consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal with higher sequence divergence. α-Synuclein is predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions. Other tissues express α-Synuclein at very low levels. The physiological role of α-synuclein is not yet well understood. However, the presence of imperfect KTKEGV lipid interacting repeats suggests that it may be involved in synaptic vesicle homeostasis.