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- Conjugation:Unconjugated
- Source:E. coli
- Species:Human
- Size:50 µg
- Storage conditions:–80 °C
- Form:Liquid
- Shipping conditions:–80 °C, dry ice
- Enzyme name:NAPRTase
- Enzyme activity:~0.27 U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1µmol nicotinic acid mononucleotide (NaMN) per min.
- Purity:98%
- Molecular weight:~58.0 kDa
- Concentration:0.5 mg/ml (Lot specific)
- Formulation:In 50 mM HEPES/KOH pH 7.5 containing 300 mM potassium chloride and 10 mM DTT.
- Cat. no.:102980-446
- Supplier No.:AG40T0105C050
Human nicotinate phosphoribosyltransferase (NAPRTase) is localized in the cytoplasm and is involved in biological processes such as NAD biosynthetic and metabolic processes, nicotinamide metabolic process, nicotinate nucleotide salvage, response to oxidative stress and water-soluble vitamin metabolic process
- UniProt link Q6XQN6: NAPRTase (human)
It functions by catalyzing the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) and is essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells. It is a crucial factor in the NAD+ biosynthesis pathway. Catalytic activity: Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.