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- Conjugation:Unconjugated
- Source:E. coli
- Size:50 µg
- Storage conditions:–80 °C
- Form:Liquid
- Shipping conditions:–80 °C, dry ice
- Enzyme name:Zmp1
- Enzyme activity:~0.5U/mg protein. Active towards the generic fluorogenic substrate for matrix metalloproteinases MMP2/MMP7 (Lit. 1).
- Purity:98%
- Molecular weight:~73.9 kDa
- Concentration:0.5 mg/ml (Lot specific)
- Formulation:In 10 mM TRIS-HCl, pH 8.0.
- Cat. no.:102980-442
- Supplier No.:AG40T0103C050
M13 endopeptidases are single-pass, transmembrane zinc-metallopeptidases responsible in human for the regulation of the biological activity of many hormones and peptides and are involved in many important processes such as blood pressure regulation (Neprilysin or NEP1), cardiovascular development (Endothelin Converting Enzyme-1 or ECE-12), prevention of haemolytic reaction (KELL) and phosphate homeostasis (PHEX)
- UniProt link O53649: Zmp1 (M. tuberculosis)
Zmp1 is a soluble enzyme member of the M13 endopeptidases family that plays a key role in Mycobacterium tuberculosis pathogenicity with a still unknown mechanism. Recently, it was shown to suppress inflammasome activation by inhibiting caspase-1 activation, thus preventing processing of pro-IL-1beta into IL-1beta and the consequent phagosome maturation.