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Specifications
- Conjugation:Unconjugated
- Source:E. coli
- Size:50 µg
- Storage conditions:–80 °C
- Form:Liquid
- Shipping conditions:–80 °C, dry ice
- Enzyme name:TDO
- Enzyme activity:Specific activity towards L-Trp: 87.0µmol/hr per mg. TDO catalyzes the oxidative opening of the L-tryptophan indole moiety to yield N-formylkynurenine (NFK).
- Purity:98%
- Molecular weight:~47.9 kDa
- Concentration:0.5 mg/ml (Lot specific)
- Formulation:In 50 mM sodium phosphate pH 8.0, containing 0.15M sodium chloride, 0.2 M imidazole and 10% glycerol.
- Cat. no.:102980-438
- Supplier No.:AG40T0101C050
Specifications
About this item
Tryptophan 2,3-dioxygenase (TDO) is a heme-containing dioxygenase catalyzing the addition of molecular oxygen across the 2,3-double bond of the indole ring of tryptophan to form N-formylkynurenine (NFK)
- UniProt link O77457: TDO (Anopheles gambiae)
In Anopheles gambiae, TDO is the only enzyme able to catalyze the first and rate-limiting step in L-Trp catabolism through the kynurenine pathway. Tryptophan is an essential amino acid for protein synthesis and also the precursor for production of a number of neurotransmitters, such as serotonin and melatonin; in mosquitoes, the kynurenine pathway is essential for eye pigmentation. Conceivably, the tryptophan-using pathways should be regulated in a coordinated manner in mosquitoes as well as in other species and TDO activation/inactivation processes could play an essential role in these phenomena.