Interleukin-4 (IL-4) is a cytokine produced by type 2 helper T cells, the Th2 cells. These cells tends to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta). In addition, mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunoglobulin class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. IL-4 promotes survival, growth and differentiation of both T and B lymphocytes, mast cells and endothelial cells. In addition, IL-4 inhibits the production of TNF, IL-1 and IL-6 by macrophages.
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- Conjugation:Unconjugated
- Protein Function:Interleukins
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Mouse
- Storage conditions:–20 °C
- Endotoxin content:<0.1EU/µg
- Gene ID:NP_067258.1
- Protein synonyms:B Cell Stimulatory Factor 1|BSF-1|Interleukin-4
- Protein/peptide name:IL-4
- Purity:98%
- Endotoxin level:Low
- Formulation:Lyophilized from 0.2µm-filtered solution in PBS (pH 7.4).
- Shipping temperature:-20 °C, Blue Ice
: VWR International
: VWR International
: VWR International
: VWR International