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- Conjugation:Unconjugated
- Protein/peptide type:Recombinant
- Source:Insect cells (Sf21)
- Species:Human
- Size:2 µg
- Storage conditions:–80 °C
- Biological activity:100-200ng are required for standard HAT assay.
- Gene ID:Q92993
- Protein synonyms:Histone Acetyltransferase HTATIP|Lysine Acetyltransferase 5|Histone Acetyltransferase KAT5|60 kDa Tat-interactive Protein
- Protein/peptide name:TIP60 (active)
- Purity:95%
- Concentration:Lot dependent (0.2-0.5mg/ml)
- Formulation:Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.
- Shipping temperature:-80 °C, Dry Ice
- Cat. no.:102980-374
- Supplier No.:AG40T0019C002
TIP60 is the catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex is required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. TIP60 directly acetylates and activates ataxia-telangiectasia mutated (ATM). In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.