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- Conjugation:Unconjugated
- Protein/peptide type:Recombinant
- Source:E. coli
- Size:10 µg
- Storage conditions:–20 °C
- Endotoxin content:<0.01EU/µg
- Gene ID:Q8NAU1
- Protein synonyms:Fibronectin Type III Domain-containing Protein 5|Fibronectin Type III Repeat-containing Protein 2
- Protein/peptide name:FNDC5
- Purity:95%
- Molecular weight:~16kDa
- Endotoxin level:Low
- Concentration:0.1mg/ml after reconstitution.
- Formulation:Lyophilized. Contains PBS.
- Shipping temperature:-20 °C, Blue Ice
- Cat. no.:102980-230
- Supplier No.:AG40B0128C010
Irisin is a recently described exercise and PGC1-alpha-induced myokine secreted by skeletal muscle in mice and humans. Irisin has been shown to induce browning of white adipose tissue, but this role has been questioned and a new function in the control of mass and strength of cortical bone has been reported. The membrane fibronectin type III domain containing protein 5 (FNDC5) can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human).