Human Recombinant FLT3 Ligand (from CHO cells)

Supplier: Adipogen

Supplier: Adipogen

About this item

FMS-like tyrosine kinase 3 ligand (FLT3L) acts as a growth factor that increases the number of immune cells (lymphocytes (B cells and T cells)) by activating the hematopoietic progenitors. It binds to FLT3 (CD135) which is found on multipotent progenitor (MPP) and common lymphoid progenitor (CLP) cells in mice. FLT3L induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3L is crucial for steady-state pDC (plasmacytoid dendritic cells) and cDC (classical dendritic cells) development. Deficiency of FLT3L causes a dramatic decrease in DC numbers, whereas increasing its availability increase in DC numbers.

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Specifications

Conjugation:
Unconjugated
Protein/peptide type:
Recombinant
Source:
CHO cells
Species:
Human
Storage conditions:
–20 °C
Endotoxin content:
<0.1EU/µg
Biological activity:
In vitro and in vivo generation of conventional and plasmacytoid dendritic cells (DC).
FLT3L increases in vivo both NK and DC cells numbers in the spleen when mice are injected intraperitoneally with 2 or 10 µg, daily for 10 days (slightly higher effect at 10 µg).
Gene ID:
P49771
Protein synonyms:
FMS-like Tyrosine Kinase 3 Ligand
Protein/peptide name:
FLT3 Ligand
Purity:
95%
Endotoxin level:
Low
Concentration:
1mg/ml
Formulation:
Liquid. In PBS (sterile).
Shipping temperature:
-20 °C, Blue Ice