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- Conjugation:Unconjugated
- Protein/peptide type:Recombinant
- Source:HEK293 cells
- Species:Mouse
- Size:3 x 10 µg
- Storage conditions:–20 °C
- Endotoxin content:<0.01EU/µg
- Gene ID:Q9WU72
- Protein synonyms:B Cell Activating Factor|CD257|Tumor Necrosis Factor Ligand Superfamily Member 13B|TNFSF13B
- Protein/peptide name:BAFF (soluble)
- Purity:90%
- Molecular weight:~26kDa (SDS-PAGE)
- Endotoxin level:Low
- Concentration:0.1mg/ml after reconstitution.
- Formulation:Lyophilized. Contains PBS.
- Shipping temperature:-20 °C, Blue Ice
- Cat. no.:102980-124
- Supplier No.:AG40B00223010
BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers.