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Specifications
- Conjugation:Unconjugated
- Protein/peptide type:Recombinant
- Source:HEK293 cells
- Species:Human
- Size:10 µg
- Storage conditions:–20 °C
- Endotoxin content:<0.1EU/µg
- Gene ID:Q9Y219
- Protein synonyms:hJ2|JAG2|Protein Jagged-2
- Protein/peptide name:Jagged-2
- Purity:90%
- Molecular weight:~150kDa (SDS-PAGE)
- Endotoxin level:Low
- Concentration:0.1mg/ml after reconstitution.
- Formulation:Lyophilized. Contains PBS + 0.02 % CHAPS.
- Shipping temperature:-20 °C, Blue Ice
- Cat. no.:102980-082
- Supplier No.:AG40A0155YC010
Specifications
About this item
Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.