IdeZ Protease (IgG-specific) is a recombinant antibody specific protease cloned from Streptococcus equi subspecies zooepidemicus that recognizes all human, sheep, monkey, and rabbit IgG subclasses, specifically cleaving at a single recognition site below the hinge region, yielding a homogenous pool of F(ab´)2 and Fc fragments

IdeZ Protease more effectively cleaves murine IgG2a than IdeS.