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Specifications
- Protein/peptide type:Recombinant
- Species:Mouse
- Size:0.05 mg
- Tag sequence:C-6 His tag
- Storage conditions:Store at −20 °C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Endotoxin content:<0.1 ng/ug (1 IEU/ug) as determined by LAL test.
- Protein synonyms:SV-40-induced 24P3 protein|Neutrophil gelatinase-associated lipocalin|Lipocalin-2|LCN2|Siderocalin LCN2|NGAL|p25
- Protein/peptide name:NGAL
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:21.9 kD
- Sequence:Gln21-Asn200
- Formulation:Supplied as a 0.2 um filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Cat. no.:75791-780
- Supplier No.:92-609
Specifications
About this item
Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes with matrix metalloproteinase-9 (MMP-9) through disulfide bonds. Similar to other lipocalin family members, Lipocalin-2 is involved in diverse cellular processes, including the transport of small hydrophobic molecules, protection of MMP-9 from proteolytic degradation, and cell signaling. Furthermore, Lipocalin-2 can tightly bind to bacterial siderophore through a cell surface receptor, possibly serving as a potent bacteriostatic agent by sequestering iron, regulating innate immunity and protecting kidney epithelial cells from ischemia–reperfusion injury. This protein is mainly expressed in neutrophils and in lower levels in the kidney, prostate, and epithelia of the respiratory and alimentary tracts. Recent evidence also suggests its role as a biomarker for renal injury and inflammation.
- Fusion-Tag: C-6 His tag
This recombinant protein can be used for biological assays. For research use only.