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Human Recombinant Dihydropteridine Reductase (from Cells)
Human Recombinant Dihydropteridine Reductase (from Cells)
Catalog # 75789-984
Supplier:  Prosci
CAS Number:  
Human Recombinant Dihydropteridine Reductase (from Cells)
Catalog # 75789-984
Supplier:  Prosci
Supplier Number:  91-662
CAS Number:  

Specifications

  • Enzyme type:
    Recombinant
  • Source:
    Cells
  • Species:
    Human
  • Size:
    0.05 mg
  • Tag sequence:
    C-6 His tag
  • Storage conditions:
    Lyophilized protein should be stored at –20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4...7 °C for 2 - 7 days. Aliquots of reconstituted samples are stable at –20 °C for 3 months.
  • Endotoxin content:
    <0.1 ng/ug (1 IEU/ug) as determined by LAL test.
  • Enzyme name:
    Dihydropteridine Reductase
  • Enzyme synonyms:
    Dihydropteridine Reductase, HDHPR, Quinoid Dihydropteridine Reductase, QDPR, DHPR
  • Purity:
    >95% as determined by reducing SDS-PAGE
  • Molecular weight:
    26.8 kD
  • Sequence:
    Ala2-Phe244
  • Formulation:
    Lyophilized from a 0.2 µm filtered solution of 20 mM TrisHCl,pH 8.0. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested applications:
    Bioassay
  • Cat. no.:
    75789-984
  • Supplier No.:
    91-662

Specifications

About this item

Dihydropteridine reductase, also known as HDHPR and Quinoid dihydropteridine reductase, QDPR and DHPR, belongs to the short-chain dehydrogenases/reductases (SDR) family

This recombinant protein can be used for biological assays. For research use only.

Fusion-Tag: C-6 His tag

QDPR exists as a homodimer. QDPR is part of the pathway that recycles a substance called tetrahydrobiopterin, also known as BH4 and tryptophan hydroxylases. The regeneration of this substance is critical for the proper processing of several other amino acids in the body. Tetrahydrobiopterin also helps produce certain chemicals in the brain called neurotransmitters, which transmit signals between nerve cells. Defects in QDPR are the cause of BH4-deficient hyperphenylalaninemia type C (HPABH4C) which is a rare autosomal recessive disorder and is lethal.