Specifications
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Size:0.05 mg
- Storage conditions:Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
- Endotoxin content:<0.1 ng/ug (1 IEU/ug) as determined by LAL test.
- Biological activity:ED50 is approximately 2 ng/ml as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts.
Specific Activity of 5 x 105 IU/mg. - Protein synonyms:IL-17|IL17|CTLA8|IL17A|IL-17A|Cytotoxic T-Lymphocyte-Associated Antigen 8|CTLA-8|Interleukin-17A
- Protein/peptide name:IL17
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:15.26 kD
- Sequence:Ile20-Ala155
- Formulation:Lyophilized from a 0.2 um filtered solution of 20mM PB, pH 7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Tested applications:Bioassay
- Cat. no.:75788-754
- Supplier No.:91-015
Specifications
About this item
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
This recombinant protein can be used for biological assays. For research use only.