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Specifications
- Description:iodoTMTsixplex™ Isobaric Mass Tag Labeling Kit
- Storage conditions:Upon receipt store all products at -20˚C
- Cat. no.:CAPI90103
- No. of Reactions:30
- Supplier No.:90103
Specifications
About this item
Thermo Scientific iodoTMTsixplex Isobaric Mass Tag Labeling Kit contains iodoTMT™ reagents and associated materials for the irreversible labeling of sulfhydryl groups.
- Specifically reacts with sulfhydryl groups (reduced, unmodified cysteine residues)
- Labeled proteins and peptides are not susceptible to reducing agents
- Options for duplex isotopic (MS) or sixplex isobaric (MS/MS) quantitation
- Can be used to study cysteine modifications (e.g. di-sulfide bridges, S-nitrosylation)
Thermo Scientific iodoTMTsixplex Label Reagents enables enable concurrent identification and multiplexed quantitation of proteins in different samples using tandem mass spectrometry. The iodoTMT™ Reagents are sets of isobaric (mass and structure) isomers that are iodoacetyl-activated for covalent, irreversible labeling of sulfhydryl (—SH) groups. Similar to iodoacetamide, iodoTMT Reagents react specifically with reduced cysteines (Cys) in peptides and proteins. IodoTMT Reagents can be differentiated by mass spectrometry (MS), enabling quantitation of the relative abundance of cysteine modifications, such as S-nitrosylation, oxidation and disulfide bonds, in cultured cells grown or treated with different conditions.