Human;Mouse;Rat Recombinant BDNF (from E. coli)

About this item

BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

Restricted Products: To process your orders without delay, please provide the required business documentation to purchase this product.

To order chemicals, medical devices, or other restricted products, please provide identification that includes your business name and shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number. Acceptable forms of identification are:

• Issued document with your organization's Federal Tax ID Number
• Government issued document with your organization's Resale Tax ID Number
• Any other Government ID that includes the business name and address

Avantor will not lift restrictions for residential shipping addresses.

Specifications

Conjugation:
Unconjugated
Protein Function:
Cytokines and Growth Factors
Protein/peptide type:
Recombinant
Source:
E. coli
Species:
Human
Rat
Mouse
Storage conditions:
Store at –20 °C prior to reconstitution.
Endotoxin content:
>0.1 ng/μg
Biological activity:
Biological Activity tests can vary. Please refer to the Product CoA for information.
Form:
Lyophilized
Gene ID:
627 P23560
Reconstitution instructions:
Reconstitution instructions can vary. Please refer to the product CoA for info.
Protease-free:
Y
Protein synonyms:
Brain-Derived Neurotrophic Factor|Abrineurin
Protein/peptide name:
BDNF
Purity:
0.98
Molecular weight:
27 kDa
Sequence:
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Endotoxin level:
Low
Formulation:
Formulation can vary. Please refer to product CoA for information.
Shipping temperature:
Ambient